正常妊娠和妊高征孕妇血浆单胺类物质含量的变化及意义

ChangesofPlasmaLevelsofMonoaminesinNormalPregnancyandPregnancy┐InducedHypertensionWomenandTheirSignificance

目的：了解孕妇体内单胺类物质含量的变化，探讨其与妊高征的关系。方法：用荧光分光光度法对１３０例正常孕妇、５８例妊高征孕妇及３２例正常非孕妇女血浆单胺类物质的含量进行测定。结果：正常孕妇从孕中期起，去甲肾上腺素（ＮＥ）的含量明显高于孕早期和正常非孕妇女（Ｐ＜０．０５）；多巴胺（ＤＡ）和５－羟色胺（５－ＨＴ）分别于孕中期和临产前明显升高（Ｐ＜０．０５）；与正常孕妇相比，中、重度妊高征孕妇ＤＡ含量随病情严重程度的增加而降低，差异有显著和极显著性（Ｐ＜０．０５和Ｐ＜０．０１），５－ＨＴ则显著升高（Ｐ＜０．０５），ＮＥ含量也有升高的趋势。结论：单胺类物质含量的变化，可能是妊高征小动脉挛缩的原因之一。

Objective:Tostudythechangesofplasmalevelsofmonoaminesinpregnantwomenandinvestigatetherelationshipbetweenthemonoaminesandpregnancyinducedhypertension(PIH).Methods:Usingfluorescencespectrophotometry,wedeterminedthecontentsofplasmamonoaminesin130normalpregnant(NP),32normalnon-pregnant(NNP),and58PIHwomen.Results:Thelevelsofnorepinephrine(NE)inNPfromthe2ndtrimestertoparturiencyweremoremarkedlyin-creasedthanthoseofthe1sttrimesterandofNNP(P<0.05).Thelevelsofdopamine(DA)and5-hydro-xytryptamine(5-HT)werealsoobviouslyincreasedatthe2ndand3rdtrimesterrespectively(P<0.05).ComparedwithNP,thecontentsofDAinmoderateandseverePIHweremarkedlyandverymarkedlydecreasedrespectively(P<0.05andP<0.01),whilethelevelsof5-HTinPIHin-creasedsignificantly(P<0.05).NEinPIHwasalsotendingtoincrease.Conclusion:ThechangesofmonoaminesmaybeoneofthecausesofsmalarteryspasminPIH.