大蒜素对糖尿病大鼠血管内皮损伤的保护作用

Protecting fucntion of Thera-Garlicin on injury of blood vessel endothelium in rats with diabetes mellitus

目的研究大蒜素对糖尿病(DM)大鼠血管内皮及血液成分的影响。方法将用四氧嘧啶造模成功的糖尿病大鼠随机分为糖尿病组、低剂量大蒜素组(10 mg/(kg.d))、高剂量大蒜素组(30 mg/(kg.d)),4周后检测大鼠血中一氧化氮(NO)、超氧化物歧化酶(SOD)、丙二醛(MDA)、胆固醇(CH)含量,并观察离体胸主动脉环的内皮依赖性舒张反应。结果大蒜素组和糖尿病组NO、MDA、SOD含量有显著性差异,胸主动脉环的内皮依赖性舒张明显改善。结论大蒜素对糖尿病大鼠血管内皮损伤有保护作用。

Objective It is to study the effect of Thera garlicin on blood vessel endothelium and ingredients of blood in rats with diabetes mellitus （DM）. Methods The rats which were successfully made to DM models by alloxan were randomly divided into DM group, low dosage Thera- Garlicin （10 mg/（kg·d） ） group, high dosage Thera Garlicin （30 mg/（kg·d） ） group. The contents of serum NO, SOD, MDA and CH in the rats were determined after 4 weeks, and the endothelium depending relaxing reaction of thoracic aorta annulation was observed. Results There were significant differences in the contents of NO, MDA and SOD between the two groups. And the endothelium depending relaxing of thoracic aorta annulation was obviously improved in Thera - Garlicin group, Conclusion Thera - Garlicin has a protecting fucntion on injury of blood vessel endothelium in rats with diabetes mellitus;