留置针肝素封管液对ITP患儿凝血功能影响的研究

A study on influence of heparin sodium for sealing of intravenous detaining needle on blood coagulation function of idiopathic thrombocytopenic purpura children

[目的]探讨留置针肝素封管液对原发性血小板减少性紫癜(ITP)患儿凝血功能的影响。[方法]将36例ITP患儿随机分为两组,A组以肝素封管液封管(62.5IU/mL),B组以生理盐水封管,检测并比较使用前后两组凝血酶原时间(PT)、部分凝血活酶时间(APTT)及血小板计数(PLT),同时观察留置针的保留时间及有无出血倾向。[结果]两组患儿PT、APTT、PLT及出血倾向发生率差异均无统计学意义(P>0.05),但A组患儿留置针保留时间明显长于B组(P<0.05)。[结论]使用肝素封管液对ITP患儿凝血功能及PLT无影响,不会加重患儿原有的出血倾向,且留置针保留时间明显长于使用生理盐水封管液。

Objective：To probe into the influence of heparin .sodium for sealing of intravenous detaining needle on blood coagulation function of children with idiopathic thromboeytopenic purpura （ITP）. Methods： A total of 36 cases of children with ITP were divided into two groups randomly （group A and B）. Tubes of intra- venous detaining needle of patients in group A were sealed by heparin sodium slution （62.5 IU/mL）, and radium chloride was used for sealing tubes for group B cases. Then prothrombin time（PT）, APTT and PLT of all children of the two groups before and after scaling tubes were checked and compared with each other. Meanwhile, both maintenance time of detaining helle and hemorrhagic tendency of all cases were observed. Results： There were no statistic significant differences in terms of IYI＂, AIYFI＂, PLT and hemorrhagic tendency between the two groups cases （P 〉0.05）. However, the maintenance time of detaining needle in group A cases was much longer than that of group B cases（P〈0.05）. Conclusion：The heparin sodium for sealing of intravenous detaining needle has no influence on blood coagulation function and blood platelets count of ITP children. And it can＇ t aggra vate ITP children＇s hemorrhagic tendency. The maintenance time of intravenous detaining needle with heparin .sodium sealing is much longer than that of radium chloride for sealing tube.