可乐定控释贴治疗儿童抽动障碍的临床研究

Clonidine skin paster versus haloperidol and tiapride in the treatment of children with Tourette's syndrome

目的:探讨可乐定控释贴治疗儿童抽动障碍的临床疗效。方法:92例TICS患儿随机分为研究组25例(予可乐定控释贴治疗)、氟哌啶醇组38例(予氟哌啶醇治疗)和泰必利组29例(予泰必利治疗),采用耶鲁抽动症整体严重度量表(YGTSS)评分并记录治疗中可能出现的不良反应,共治疗12周。结果:治疗第12周末研究组有效率为84.0%,氟哌啶醇组为68.4%,泰必利组为65.5%(P均>0.05);不良反应较轻且发生率(16.0%)明显低于氟哌啶醇组(65.8%)(P<0.01)和泰必利组(48.3%)(P<0.05);平均显效时间研究组(45.65±8.57)d与氟哌啶醇组(40.81±6.79)d和泰必利组(42.34±7.92)d相当(P均>0.05);研究组YGTSS总分减分率(64.90±10.49)%高于氟哌啶醇组(42.73±11.90)%和泰必利组(40.63±13.58)%(P均<0.05)。结论:可乐定控释贴治疗抽动障碍疗效优于氟哌啶醇和泰必利,不良反应较轻且发生率低。

Objective ：To evaluate the efficacy and tolcrability of clonidine skin paster in comparison with haloperidol and tiapride in the treatment of children with Tourette＇s syndrome （TS）. Methods： Total 92 TS patients were divided into study group of 25 cases （treated with elonidine skin paster）, haloperidol group of 38 cases （treated with haloperidol） and tiapride group of 29 cases （treated with tiapride）, and the period of treatment was 12 weeks. All the cases were scored by the Yale Global Tic Severity Scale （YGTSS）, and there were no significant difference in YGTSS scores between three groups at the beginning of the study. Results： The proportion of efficacious cases in clonidine skin paster group （84.0%） appeared slightly higher than that in haloperidol group （68.4%, P 〉 0.05）and tiapride group （65.5%, P 〉 0.05） ; the proportion of side effects in study group （ 16.0 % ） was significant lower than that in haloperMol group （65.8 %, P 〈 0.01 ） and tiapride group （48.3 %, P 〈 0. 05 ） ; there was no difference in mean remission time between three groups （45.65± 8.57） d, （40.81 ± 6.79） d and （42.34 ± 7.92） d respectively （ P 〉 0.05 ）. Clonidine skin paster produced a higher reduction in the YGTSS （64.90 ± 10.49） % than haloperidol （42.73 ± 11.90） % （ P 〈 0.05） and tiapride （40.63 ± 13.58） % （P 〈 0.05）. Conclusions： In this pilot study, elonidine skin paster was demonstrated a better efficacy than haloperidol and tiapride in the treatment of children with TS, and its side effects was mild and rare.