氨溴索辅助治疗新生儿胎粪吸入综合征

Efficacy of ambroxol in the treatment of meconium aspiration syndrome

目的:探讨氨溴索辅助治疗新生儿胎粪吸入综合征的效果。方法:将46例胎粪吸入综合征患儿随机分为治疗组(26例)和对照组(20例),两组均采用呼吸机辅助通气及常规治疗,治疗组在上述治疗的基础上加用氨溴索静脉滴注。结果:治疗组8 d后X线胸片好转率及治疗后72 h、84 h、96 h的平均气道压(MAP)和氧合指数(PaO2/FiO2)等指标分别与对照组相比,差异均有统计学意义(P<0.05)。结论:氨溴索辅助治疗新生儿胎粪吸入综合征效果满意,未见明显不良反应。

Objective：To investigate the therapeutic efficacy of ambroxol in the treatment of meconium aspiration syndrome, Methods： 46 eases of meconium aspiration syndrome newborns were divided into the treatment group （26 eases） and the control group （20 cases）. Results： The improvement rates of chest X-ray after 8 days, mean airway pressure （MAP） and PaO2/FiO2, after 72 h, 84 h and 96 h in two groups were significantly different （P 〈 0.05）, Conclusions： The ambroxol could control the attack of meconium aspiration syndrome without side effect.