摘要
目的研究溃疡性结肠炎(UC)患者结肠黏膜中白细胞介素-8(IL-8)、IL-15、IL-18的表达情况以及与UC疾病严重程度的关系。方法采用免疫组化法检测UC患者及正常对照组结肠黏膜中IL-8、IL-15、及IL-18的表达情况。结果中重度组IL-8阳性细胞数(216.8±24.9)多于轻度组(165.7±27.6)(P<0.01),轻度组多于缓解期组(88.5±21.6)(P<0.01),缓解期组又多于正常对照组(52.1±18.7)(P<0.05)。中重度组IL-15阳性细胞数(29.5±4.2)多于轻度组(18.7±2.9)(P<0.05),轻度组多于缓解期组(11.3±2.6)(P<0.05),缓解期组又多于正常对照组(3.9±1.1)(P<0.01)。中重度组IL-18阳性细胞数(115.7±24.6)多于轻度组(68.7±18.6)(P<0.01,轻度组多于缓解期组(47.3士12.6)(P<0.05),缓解期组又多于正常对照组(21.5±7.9)(P<0.05)。结论活动期UC患者结肠黏膜中IL-8、IL-15及IL-18的表达较缓解期、单纯结肠息肉者升高,且与病情严重程度有关。IL-8、IL-15及IL-18在UC的发病过程中起到了重要作用。
Objective To investigate the expression of IL-8 ,IL-16 and IL-17 in colonic mucosa in ulcerative colitis （ UC ） and study the relationship between the three parameters and UC severity. Methods The expression of IL-8 ,IL-15 and IL-18 in colonic mucosa were examined by immunohistochemistry in UC and normal controls. Resuits The positive cells of IL-8 in moderate or severe UC （ 216.8±24.9 ） were more than those in mild UC （ 165.7±27.6） （ P 〈0.01 ） ,which were more in the latter than those in remission group （ 88.5 ± 21.6 ） （ P 〈0. 01 ）. Positive cells in remission group were more than those normal controls（ 52.1 ± 18.7 ） （ P 〈 0.05 ）. The positive ceils of IL-15 in moderate or severe UC （29.5 ±4.2 ）were more than those in mild UC（18.7 ± 2.9 ） （P 〈 0. 05 ）, which were more in mild UC than those in remission group （ 11.3±2.6 ） （ P 〈 0.05 ）. Positive cells in remission group were more than in normal controls （3.9±1.1 ） （ P 〈 0.01 ）. The positive cells of IL-18 in moderate or severe group（ 115.7±24.6 ） were more than that in mild UC （68.7 ± 18.6 ） （ P 〈 0.01 ）. The latter were more than that in remission group（47.3±12.6） （P 〈 0.05）. Positive cells in remission group were more than in normal controls（21. 5 ±_ 7.9 ） （P 〈 0.05 ）. Conclusion The expression of IL-8, IL-15 and IL-18 in colonic mucosa is higher in active UC than those in inactive UC and in normal controls, which are related to the severity disease＇s. The three indexes might play the important role in the development of disease＇s.
出处
《中国综合临床》
北大核心
2006年第12期1095-1097,共3页
Clinical Medicine of China
