摘要
目的:观察转化糖注射液对各种需要静脉补充能量及体液的住院患者血糖、胰岛素水平的影响,并评价其安全性。方法:采用随机、双盲、对照的多中心临床试验。共入选病例240例,试验组(120例)静脉滴注转化糖注射液500ml/d,对照组(120例)静脉滴注葡萄糖注射液500ml/d,疗程均为3天。给药期间检测患者的血糖、胰岛素,给药前后作心电图、血尿常规、肝肾功能及血尿酸、电解质等检查,密切观察患者的临床症状及体征变化。结果:转化糖组的血糖及胰岛素水平的波动小于葡萄糖组(P<0.05),试验前后的生命体征、血尿常规、肝肾功能、电解质、心电图等均未出现与药物相关的异常变化。结论:转化糖对血糖及胰岛素水平的影响小于葡萄糖,其安全性与葡萄糖注射液相当。
OBJECTIVE:To observe the effect of invert sugar injection on blood glucose and insulin levels of in-atients who need infusion of energy and liquid, and to evaluate the safety of invert sugar injection. METHODS: We conducted a randomized double blind controlled muhicenter trial. Of a total of 240 patients were enrolled, 120 (trial group) were randomly assigned to received invert sugar injection at a dose of 500ml/d by intravenous drip for 3 days and another 120 and kidney, and blood uric acid and electrolyte before and after administration were also determined. Symptoms and signs of the patients were closely monitored. RESULTS: Blood glucose and insulin levels had a less change in trial group than in control group ( P 〈 0.05). Drug-associated abnormal changes including vital signs, routine tests of blood and urine, tests of functions of liver and kidney, electrolyte, cardiogram ect were not noted. CONCLUSION: Invert sugar injection has less effect on blood glucose and insulin lcycls as against glucosc injection, but its safety equals to the latter.
出处
《中国医院用药评价与分析》
2006年第5期271-273,共3页
Evaluation and Analysis of Drug-use in Hospitals of China
关键词
转化糖
葡萄糖
血糖
胰岛素
多中心试验
invert sugar
glucose
blood glucose
insulin
multiple center clinical trial