单方舒巴坦制剂与β-内酰胺类抗生素联合应用预防急腹症术后感染并发症的临床观察

Sulbactam in Combination with β-lactam Antibiotics in the Prevention of Postoperative Infection of Acute Abdominal Syndrome

目的:评价β-内酰胺酶抑制剂舒巴坦与β-内酰胺类抗生素按一定比例联合应用于急腹症手术后患者预防感染并发症的疗效。方法:回顾性分析114例急腹症及腹部外伤患者,分单用β-内酰胺类抗生素组及联合应用β-内酰胺酶抑制剂舒巴坦组。观察比较两组手术前后血白细胞、体温及术后感染并发症发生率等指标。结果:联合应用舒巴坦较单独使用β-内酰胺类抗生素能明显地减轻术后全身炎症反应症状,术后感染并发症的发生率明显降低。结论:单方舒巴坦制剂副作用小,安全有效,值得更进一步的临床推广应用。

OBJECTIVE： Tp evaluate the effects of β- lactamase inhibitor and sulbactam β-lactam antibiotics abdominal syndrome. METHODS： A total of 114 patients with acute abdominal syndrome and abdominal injuries were randomly assigned to receive β- lactam antibiotics ＇alone or in combination with sulbactam. Indexes including white cell counts, temperature, and proportions of postoperation infection complications etc before and after operation were monitored. RESULTS： Postoperative systemic inflammatorome was significantly alleviated and incidences of postoperative infection complication were significantly lower in patients receiveing β- lactam antibiotics in complications with sulbactam than those receiving β- lactamase antibiotics alone. CONCLUSION： Sulbactam is safe and effective yet with little side effect, and it deserves to be widely used in the clinic.