四川省医疗机构217例克林霉素致不良反应报告分析

Clindamycin-induced ADRs:Analysis of 217 Cases in Medical Institutions of Sichuan Province

目的:探讨克林霉素致不良反应发生的一般规律,为临床合理用药提供参考。方法:对四川省药品不良反应监测中心数据库2002年～2006年8月收集的克林霉素致217例不良反应报告进行分类统计、分析。结果:不良反应涉及8种系统及性质类型,位居前3位的分别是皮肤及其附件损害、泌尿系统损害及过敏性休克;导致因素包括克林霉素化学性质、制剂过程及不合理用药等。结论:应从多方面对其加以监测,以避免克林霉素不良反应的发生。

OBJECTIVE： To discuss the adverse reactions （ADRs） induced by clindamycin so as to provide guidance for clinical rational use of this medicine. METHODS： Data regarding clindamycin-induced ADRs in the database of Sichuan ADR monitoring center collected from 2002 to Aug. 2006 were classified and analyzed statistically. RESULTS： ADRs were seen in 8 organs/ systems, dominating the first 3 places were damages of skin and its appendages, urinary system and allergic shock, which were caused by factors including the chemical property, the preparation process, non- rational use of clindamycin etc. CONCLUSION： The use of clindamyein should be monitored from different levels so as to avoid ADRs.