摘要
前列腺癌是老年男性最常见的恶性肿瘤之一,PET在其早期诊断和准确分期方面具有重要价值。^(18)F-氟代脱氧葡萄糖(^(18)F-FDG)PET对前列腺癌的检出并不敏感,也不能可靠进行淋巴结分期,但^(18)F-FDG摄取与疾病进展程度相关。^(11)C-胆碱PET诊断前列腺癌的准确率高,在淋巴结及骨转移的检出方面也明显优于^(18)F-FDG PET,但其半衰期短而限制了临床应用。^(18)F-胆碱的肿瘤摄取与^(11)C-胆碱相似,但在泌尿系统排泄较高。其他示踪剂如^(11)C-乙酸、^(11)C-甲硫氨酸、^(18)F标记的雄激素等在前列腺癌的诊断、分期及疗效评价方面也具有一定价值。
Prostate cancer is one of the most common malignancies in old men, positron emission tomography is very valuable in early diagnosing and accurately staging of prostate cancer. ^18F- fluorodeoxyglucose （^18F-FDG）PET is not sensitive in detection and reliable on staging of prostate cancer, but the uptake of ^18F-FDG correlates with the stage of prostate cancer. ^11C-choline PET is accurate in diagnosis of prostate cancer, and it is superior to ^18F-FDG PET in detection of metastases in lymph nodes and bone. But its short half-life limits the clinic applying in prostate cancer. The uptake of ^18F-choline in prostate cancer is similar to ^11C-choline, but its excretion in urinary system is much higher than ^11C- choline. The other tracers such as ^11C-acetate, ^11C-methionine and 16β-^18F-fluoro-5α-dihydrotestosterone are also valuable in diagnosing, staging and evaluating the effect of treatment of prostate cancer.
出处
《国际放射医学核医学杂志》
2006年第5期283-286,共4页
International Journal of Radiation Medicine and Nuclear Medicine
