超小超顺磁性氧化铁粒子标记免疫细胞在多发性硬化症动物模型MRI中的应用

MRI of animal models of multiple sclerosis with ultrasmall superparamagnetic iron oxide labeling immune cells

超小超顺磁性氧化铁粒子(USPIO)是一种外周包裹右旋糖酐的氧化铁纳米颗粒,可以被多种细胞吞噬,主要为单核巨噬细胞。由于其含铁,在T2和T2*加权磁共振(MR)图像上产生低信号。多发性硬化症(MS)是一种发生在中枢神经系统的自身免疫性脱髓鞘性疾病,实验性变态反应性脑脊髓炎(EAE)为其常用的动物模型,T细胞、单核巨噬细胞在疾病的发生、发展中起着重要作用,参与病程的各个阶段。USPIO标记免疫细胞MRI可以在体监测MS、EAE病灶的炎性细胞浸润情况,对疾病的复发、发展、早期诊断以及疗效监测均具有重要意义。

Ultrasmall superparamagnetic iron oxide （USPIO） are dextran-coated iron oxide nanoparticles that are internalized into a variety of cells, among which are mainly cells of the mononuclear phagocytic system. Owing to the presence of iron, they produce a susceptibility effect that is observable on T2- and T2^＊-weighted MR images as low signal intensity, Multiple sclerosis （MS） is an autoimmune demyelinating disease of the central nervous system. Experimental autoimmune encephalomyelitis （EAE） is a commonly used animal model. T cells and macrophages play an important role in disease initiation and progression in MS and EAE. They are involved in different phases of disease, MRI with USPIO can monitor inflammation in MS and EAE in vivo. This MRI technique has great importance in monitoring 6isease relapse, development, and therapeutic effect.