维吾尔族2型糖尿病患者颈动脉粥样硬化危险因素的相关分析

Analysis on the relative risk factors of carotid atherosclerosis in Uygur patients with type 2 diabetes mellitus

目的:探讨维吾尔族2型糖尿病颈动脉粥样硬化相关的危险因素。方法:收集2003-01/2005-05在新疆医科大学第一附属医院收治的146例维吾尔族2型糖尿病患者,进行颈动脉B超检查,测定内中膜厚度及有无粥样硬化斑块,以内中膜厚度>度1.2mm为斑块形成标准。记录临床资料,计算体质量指数,测定糖化血红蛋白、血压、总胆固醇、三酰甘油、高、低密度脂蛋白胆固醇、脂蛋白α、凝血酶原时间、活化部分凝血酶原时间、凝血酶时间和纤维蛋白原。结果:146例全部完成测试进入结果分析。①颈动脉粥样硬化的检出率为51.8%,146例根据有无颈动脉粥样硬化分为2组:粥样硬化组76例和非粥样硬化组70例。②粥样硬化组年龄、病程、总胆固醇、低密度脂蛋白胆固醇、纤维蛋白原显著高于非粥样硬化组[(57.75±3.46),(51.21±3.23)岁;(5.52±0.58),(4.45±0.43)年;(4.72±0.47),(4.21±0.56)mmol/L;(3.29±0.53),(2.33±0.45)mmol/L;(4.52±0.76)(3.49±0.49)g/L;P均<0.05]。③多元Logistic回归分析显示,年龄、低密度脂蛋白胆固醇、纤维蛋白原进入方程,且OR值均大于1,P<0.01。结论:年龄、低密度脂蛋白胆固醇和纤维蛋白原是维吾尔族2型糖尿病颈动脉粥样硬化的独立危险因素。

AIM： To analyze the relative risk factors of carotid atherosclerosis （ATS） in type 2 diabetes mellitus （DM） of Uygur people. METHODS： A total of 146 Uygnr patients of type 2 DM were selected from the First Affiliated Hospital of Xinjiang Medical University from January 2003 to May 2005. All the patients underwent carotid artery Bmode ultrasonography were adopted to detect their intima-media thickness （IMT） and ascertain atherosclerotic plaque, taking IMT 〉 1.2 mm as the standard. According to the clinical data, all the patients were measured body mass index, glycosylated haemoglobin, blood pressure, total cholesterol （TC）, triglyceride, high density lipoprotein-cholesterol （HDL-C）, low density lipeprotein-cholesterol （LDL-C）, α-lipeprotein, prothrombin time, activated partial thromboplastin time, thrombin time, fibrinogen （Fg）. RFSULTS： All 146 patients completed the tests and entered the result analysis. ①The detectable rate of carotid ATS in Uygur patients was 51.8%. And the patients were divided into ATS group （n=76） and non-ATS group （n=70） according to the appearance of ATS. ②The levels of age, durations of DM, TC, LDL-C and Fg in patients with ATS group were significantly higher than that of non-ATS group [（57.75±3.46）, （51.21±3.23） years old; （5.52±0.58）, （4.45±0.43） years; （4.72±0.47）, （4.21±0.56） mmol/L; （3.29±0.53）, （2.33±0.45） mmol/L; （4.52±0.76）, （3.49±0.49） g/L; P 〈 0.05]. ③The multiple Logistic analysis showed that age, LDL-C and Fg were involved in the equation （OR 〉1, P 〈 0.01）. CONCLUSION： Age, LDL-C and Fg are the independent risk factors of carotid ATS in type 2 DM of Uygur patients.