运动与Fas介导的心肌、骨骼肌和淋巴细胞凋亡(英文)

Exercise and Fas mediated apoptosis in cardiomyocytes, skeletal muscle cells and lymphocytes

目的:分析Fas介导细胞凋亡的可能机制,探讨运动与Fas介导心肌、骨骼肌、淋巴细胞凋亡的关系,从新的认识层次解释运动训练状态下组织细胞损伤的变化,对过度训练的预防与治疗提供科学的理论依据。资料来源:采用计算机检索springlinker,pubmed数据库1994-01/2004-12Fas介导骨骼肌、心肌、淋巴细胞凋亡的相关文章,检索词为“Fas,apoptosis,exercise,skeletalmuscle,cardiomyocyte,lymphocyte”,并限定文章的语种类为“English”。同时利用计算机检索中国期刊全文数据库1994-01/2004-12的相关文章,限定文章语言种类为中文,检索词“运动,细胞凋亡,骨骼肌,心肌,淋巴细胞”。资料选择:对资料进行初审,纳入标准:关于Fas介导心肌、骨骼肌、淋巴细胞凋亡的研究。排除标准:排除重复性研究。资料提炼:共收集到符合上述要求的文献58篇,排除29篇重复性研究,29篇符合纳入标准。资料综合:细胞凋亡是一种由基因控制的细胞自主性死亡过程,其性质为生理性细胞死亡,Fas作为诱发细胞凋亡的死亡因子,在调控细胞凋亡中有着重要的生物学意义。对运动与Fas介导细胞凋亡信号传导机制的研究,将会从新的认识层次解释运动训练状态下组织细胞损伤的变化,对过度训练的预防与治疗提供科学的理论依据。此外,Fas在许多肿瘤、免疫系统疾病、脊髓损伤中起重要作用。结论:对运动与Fas介导凋亡的深层次研究,可能会揭示治疗疾病的机制带来新的运动治疗方法,对促进人类健康无疑有重要实际意义。

OBJECTIVE： To analyze the possible mechanism of Fas mediated apoptosis, investigate the correlation of exercise with apoptosis of cardiomyocytes, skeletal muscle and lymphocytes, and explain the changes of histocyte injury under exercise training from a new level of recognition, so as to provide scientific theoretical evidences for the prevention and treatment of overtraining. DATA SOURCES： A computer-based online search of Springlinker and Pubmed databases was undertaken to identify articles related to Fas mediated apoptosis of cardiomyocytes, skeletal muscle and lymphocytes published in English from January 1994 to December 2004 by using the keywords of ＂Fas, apoptosis, exercise, skeletal muscle, eardiomyocyte, lymphocyte＂. Meanwhile, Chinese relevant articles published from January 1994 to December 2004 were searched in the Chinese journal full-text database with the keywords of ＂apoptosis, exercise, skeletal muscle, cardiomyocyte, lymphocyte＂ in Chinese. STUDY SELECTION： The data were checked firstly. Inclusive criteria： studies related to Fas mediated apoptosis of cardiomyocytes, skeletal muscle and lymphocytes. The repetitive ones were excluded. DATA EXTRACTION： Totally 58 literatures were collected, 29 repetitive studies were excluded, and the other 29 were accorded with the inclusive criteria. DATA SYNTHESIS： Apoptosis is a gene-controlled process of spontaneous death for cells, and it is the physiological cell death. As a death factor inducing apoptosis, Fas is of important biological significance in regulating apeptosis. The study on exercise and the mechanism of apeptosis signal conduction will explain the changes of histocyte injury under exercise training from a new level of recognition, and provide scientific theoretical evidences for the prevention and treatment of overtraining. Besides, Fas plays an important role in various tumors, diseases of immune system and spinal cord injury. CONCLUSION： The deeper investigation on exercise and Fas mediated apoptosis may disclose the mechanism for the treatment of disease, and intreduce new methods of exercise treatment, which undoubtably has important practical significance in accelerating healthy of human being.