2型糖尿病患者支气管黏膜超微结构的病理变化

THE PATHOLOGICAL CHANGES OF ULTRASTRUCTURE IN BRONCHIAL MUCOSA OF TYPE 2 DIABETIC PATIENTS

目的探讨2型糖尿病患者支气管黏膜组织超微结构的病理变化。方法对2型糖尿病合并肺部肿瘤或结核患者,行支气管镜检查时于不同肺段支气管取非病灶支气管黏膜及黏膜下组织,行超微病理检查。结果支气管黏膜下微血管基板弥漫性增厚,多呈洋葱皮样、卷云状改变,基板周围有蛋白质沉着;毛细血管周围可见不规则高电子密度物质沉着,血管管腔狭窄甚至闭锁;内皮细胞及周细胞有暗细胞变,粗面内质网池扩张,大吞噬体(囊泡)形成。结论支气管黏膜及其周围组织均显示特征性糖尿病性病理改变,支气管亦为糖尿病“攻击”的靶器官。

Objective To investigate the pathological changes of uhrastructure of mucosa in various bronchial segments from type 2 diabetic patients. Methods Sixteen cases of type 2 diabetic patients were selected, 2-3 pieces of bronchial mucosa and submucosal tissue of the lesion were taken from various bronchi during bronchoscopy and these samples were observed under a transmission electron microscope. Results The basal lamina of bronchial capillary were diffusely thickened and mostly showed onion-skin like change, protein deposited around and mixed with basal menbrance; irregular highly electron dense materials were found to deposite around capillary, capillary lumen became narrow or even collapsed, neutrophilic leucocyte marginated in lumen and adhered with endothelium ; protein deposited in the interstitial; endothelial cells and pericytes had dark cell changes. The cistern of rough endoplasmic reticulum dilated and vesicle formed. Conclusion Bronchial mucosa and its surrounding tissues show characteristic pathological changes of diabetes, bronchial is also the target organ of chronic diabetic damage.