纳米羟基磷灰石/聚酰胺66复合生物活性人工椎体在胸腰椎爆裂骨折中的应用

Treatment of thoracolumbar burst fractures with bioactive artificial vertebrae of nano-hydroxyapatite and polymide 66

目的探讨自行研制的纳米羟基磷灰石/聚酰胺66(n-HA/PA66)复合生物活性人工椎体在胸腰椎骨折中恢复椎体结构和高度的作用。方法从2003年12月至2006年2月,行胸腰椎爆裂骨折前路减压、n-HA/PA66复合生物活性人工椎体移植重建椎体结构共38例,其中男29例,女9例；年龄17～63岁,平均35．6岁。结果随访6～21个月(平均8个月),植入体3～4个月愈合,重建的椎体高度无降低,术前神经损伤功能有不同程度恢复。结论n-HA/ PA66复合生物活性人工椎体可有效恢复爆裂、压缩椎体的高度和结构,并能与椎体愈合,起到有效重建椎体结构的作用,可以临床推广使用。

Objective To investigate the efficacy of the bioactive artificial vertebrae of a nanohydroapatite crystals and polyamide 66 composite （n-HA/PA66） to restore the height and architecture of thoracolumbar burst fracture. Methods From December 2003 to February 2006, 38 patients （29 males and 9 females） with a mean age of 35.6 years （17-63 years） were treated surgically through anterior approach for decompression and implanted with the bioactive artificial vertebrae of n-HA/PA66 composite to reconstruct the structure of the thoracolumbar burst fractured vertebra. Results All the patients were successfuly followed-up for an average of 8 months, ranging from 6 to 21 months. The bioactivc artificial vertebrae of n-HA/PA66 composite were fused with the receptor bone 3-4 months alter operation, The neurological function of the patients was restored partially or completely. The thoracolumbar spine was stable during physical examination and the height of thoracolumbar burst fractured vertebrae that had been restored did not change during the follow-up. Conclusions Our results show the bioaetive artificial vertebrae of n-HA/PA66 can restore the height and structure of thoracolumbar burst fractured vertebrae and reconstruct the structure of the thoracolumbar vertebrae effectively, indicating that the bioactive artificial vertebrae of n-HA/PA66 can be used extensively in clinical spinal surgery.