内地、沿海治疗急性荨麻疹3569例口服H_1受体拮抗剂使用分析

Analysis on the Drug Utilization of Oral H_1-receptor Antagonist on Treatment of Acute Urticaria in An Inland and A Coastal Hospital

目的了解内地和沿海两家医院治疗急性荨麻疹患者使用口服H1受体拮抗剂情况。方法应用总金额排序法及用药频度（DDDs）排序法对2004～2005年内地和沿海两家医院治疗急性荨麻疹3569例使用口服H1受体拮抗剂的情况进行比较分析。结果相比而言，内地某医院急性荨麻疹患者少，H1受体拮抗剂的使用量高；沿海某医院急性荨麻疹患者多，H1受体拮抗剂的使用量低，采用联合疗法更常见。内地某医院处方药量6、7天更常见，而沿海某医院3、4天为多。结论沿海地区急性荨麻疹患者多于内地。咪唑斯汀、氯雷他啶、酮替芬等是目前治疗急性荨麻疹的一线H1受体拮抗刺。

Objective To investigate the drug utilization of oral H1- receptor antagonist on treatment of acute urticaria. Methods The orders of total cost and DDDs were employed to compare the use of oral H1-receptor antagonist on treatment of 3569 cases of acute urticaria in an inland hospital and a coastal hospitalin 2004-2005. Results Ourresuhsshowedthat the patients of acute urticaria were low and the dosage of oral H1-receptor antagonist was high in the inland hospital as compared with high and low in the coastal hospital, and longer prescription day for the former. Conclusions Acute urticaria was much more in coastal region than in inland region, and mizolastine,loratadine and ketotifen were still the first-line drug utilization on treatment of acute urticaria in oral H1-receptor antagonist.