砂半理中汤合小陷胸汤治疗胃食管反流疾病62例

Clinical Observation of “Shaban Lizhong Decoction” and “Xiaoxianxiong Decoction” in Treating Gastroesophageal Reflux Disease in 62 Cases

目的观察砂半理中汤合小陷胸汤治疗胃食管反流性疾病的临床疗效。方法将121例患者随机分为治疗组(62例,采用砂半理中汤合小陷胸汤加减治疗)和对照组(59例,采用泰胃美和吗丁啉治疗),治疗8周后观察两组患者症状问卷调查评分和内镜分级评估的变化情况。结果治疗组治疗后的症状问卷平均积分为与治疗前相比有显著下降(P<0.01),与对照组治疗后比较有显著性差异(P<0.01),同时较对照组在改善烧心、泛酸和反食的程度及频度方面有明显差异(P<0.05);两组治疗后内镜评分均明显下降(P<0.05),但组间比较无显著性差异(P>0.05)。结论砂半理中汤合小陷胸汤治疗胃食管反流性疾病有较理想的近期疗效,能有效改善烧心、反胃等主要症状和内镜下病变程度。

Objective To observe the clinical effects of ＂Shaban Lizhong Decoction＂ and ＂Xiaoxianxiong Decoction＂ in the treatment of gastroesophageal reflux disease. Methods 121 subjects were randomized into two groups： treatment group in which 62 cases were treated by above two Decoctions and control group in which 59 cases were treated by Tagamet and Motilium, with a course of 8 weeks. Questionnaire scoring and endoscopic assessment were performed. Results In treatment group,the questionnaire score decreased obviously （P 〈 0.01） and clinical symptoms improved,with better results than control group （P 〈0.01,P〈0.05）;endoscopic scores fell obviously in both groups （P〈 0.05）, but with no difference between them（P〉0.05）. Conclusion Combined use of these two Decoctions are fairly effective against gastroesophageal reflux disease.