壳聚糖/聚乙交酯三维编织物的力学性能

Mechanical Properties of Three-Dimensional Braids of Chitosan and Polyglycolide

选择合适的生物材料和适宜的制备方法是实现组织修复、重建的重要环节．采用三维四步圆型编织方法,由壳聚糖和聚乙交酯(PGA)纤维制备绳索状三维编织物,研究其拉伸力学特性．研究结果表明：壳聚糖三维编织物的拉伸曲线与天然肌腱相似；直径为3．5mm的壳聚糖三维编织物在湿态下的最大拉伸载荷为50～85N,远低于其干态下值(140～225N),添加轴向纱对其无显著影响；在编织纱中掺入PGA纤维,可显著提高三维编织物的最大拉伸裁荷；PGA含量较高的壳聚糖/PGA三维编织物预期可以用作人工肌腱材料．

Rope-like three-dimensional （3D） braids were prepared from chitosan and polyglycolide （PGA） fibers by means of 4-step 3D tubular braiding technique. Mechanical properties of the braids were studied. The results show that the appearance of tensile curves of chitosan braids is similar to that of natural tendon. The ultimate tensile load of chitosan braids with 3.5 mm in diameter are 50-85 N in wet state, much lower than their values （ 140-225 N） in dry state. The ultimate tensile load shows no significant increase when axial yams are added into the chitosan braids. The ultimate tensile load of the 3 D braid increases significantly by incorporating PGA fibers into the braiding yam. It is supposed that 3D chitosan/PGA braids with higher PGA content would be suitable for the biomaterial of artificial tendon.