子宫内膜异位症术后米非司酮的疗效观察

Clinical effects of Mifepristone on patients with endometriosis after operation

目的探讨米非司酮用于子宫内膜异位症术后治疗的临床疗效与副反应。方法选择子宫内膜异位症术后病例90例,随机分为两组米非司酮组45例,自月经周期第1天开始口服米非司酮,每日1次,每次10mg;孕三烯酮组45例,自月经周期第1天开始,3d后服用第2次,每周2次,每次2.5mg。疗程均为6个月。观察两组症状、体征改善情况,用药后的副反应。结果两组症状、体征缓解率相似。米非司酮组潮热、阴道出血、体重增加和痤疮等副反应发生率明显低于孕三烯酮组(P<0.05);米非司酮组无1例出现肝功能异常,而孕三烯酮组出现肝功能异常率为40%,两组比较差异有显著性(P<0.01)。米非司酮组停药后基础体温上升和月经复潮时间较孕三烯酮组为短。结论手术后加用米非司酮可明显改善患者症状和体征,疗效与孕三烯酮类似,但副反应明显减少。

[Objective] To investigate the clinical effects and side effects of Mifepristone on severe endometriosis compare. [Methods] 90 patiends suffered from postoperafive-endometriosis were selected and divided randomly into two groups. The Mifepristone group （45 patients） was administered tablets of Mifepristone 10 mg once a day, whereas the Nemestran group（45 patients） was administered tablets of Nemestran 2.5 rag once, twice a week, for 6 months and followed up for changes of symptoms and signs, side effects in both groups. [Results] During treatment symptoms and signs were remarkbly relieved in both groups. Side effects including hot flushes, irregular vaginal bleeding, weigth gain and acne, were less commonly seen in group Mifepristone as compared with group Nemestran. Abnormal rate of ALT of the Mifepristone group was separately, the Nemestran group was 40% respectively.The differences in the groups had obvious statistic significance. The time of renew of menstruation and raise of basal body temperature of Mifepristone group was shorter than Nemestran group. [Conclusion] Mifepristone is equally effective to patients when combined with conservative surgery in the management of endometriosis with fewer side effects.