肝复康对阻塞性黄疸肝损害的预防作用的实验研究

Preventive effect of Gan-Fu-Kang on liver injury in experimental obstructive jaundice

目的观察中药肝复康对实验性阻塞性黄疸所致肝损害的预防作用。方法实验分3组。Ⅰ组假手术对照组,Ⅱ组阻塞性黄疸组,Ⅲ组肝复康预防治疗组。观察指标包括血清直接胆红素、丙氨酸转氨酶、血清内毒素、肝细胞浆内游离钙和肝脏组织病理学变化。结果Ⅱ组上述各指标水平均明显增高,而Ⅲ组均呈不同程度的低值,与Ⅱ组相比差异有显著性(P<0.05)。肝脏组织病理学显示,预防应用肝复康能显著减轻肝细胞变性、坏死及纤维组织形成。结论肝复康用于阻塞性黄疸所致肝脏损害的预防,可将抗内毒素血症与拮抗肝细胞浆内游离钙离子浓度升高的作用结合起来,有望延缓肝损害的进程。

[ Objective ] To investigate the preventive effect of Gan-Fu-Kang on liver injury in experimental obstructive Jaundice. [Methods] SD rats were divided randomly into three groups： Group Ⅰ, normal group; Group Ⅱ, obstructive jaundice model group; Group Ⅲ, Gan-Fu-Kang group. Serum endotoxin, intracellular free Ca^3＋ concentration and pathologic changes of the liver were observed. [Results] Elevated serum endotoxin and intracellular free Ca^2＋ concentration were markedly decreased and liver injure was also significantly alleviated when obstructive jaundice rats were intragastrically given Gab-Fu-Kang once a day. （P〈0.05） [ Conclusion] Gan-Fu- Kang showed effects not only on anti-endotoxemia, but also against intraeellnlar free Ca^2＋. This herbal medicine can prevent the progress of liver injure.