类风湿病患者口服通痹灵片后士的宁血药浓度观察分析

Observation of Serum Concentration of Strychnine in Patients with Rheumatoid Arthritis Treated with TONGBILING Tablet

为了探讨中药制剂通痹灵片的安全性，本文对３２例类风湿病患者连续口服通痹灵片后的第１个月和第２个月，用高效液相色谱法（ＨＰＬＣ）检测其士的宁血药浓度，结果发现：３２例患者士的宁血浓度值在０．０５１～０．７８１ｍｇ／Ｌ范围，远低于士的宁中毒血浓度值２ｍｇ／Ｌ，而且未发现肝肾功能损害。说明通痹灵片的血浓度值在０．０５１～０．７８１ｍｇ／Ｌ范围是安全的，但因个体差异大，有待进一步研究。

Serum concentration of Strychnine,the main components of Tongbiling,was determinedonce a month with HPLC method in thirty-two patients with rheumatoid arthritis treated withTongbiling tablets. The result showed that the serum concentrations of Strychnine were between0.051～0.781mg/L,which were significantly lower than its toxic concentration(2mg/L),P<0 05.No side effect was found in liver and kidney functiontests;It indicates that administration of Tongbiling tablets with this range of serum concentration is safe.Further study remains to be done with consideration of the individual discrepancies.