住院精神分裂症患者伴发非酒精性脂肪肝情况

Non-alcoholic Fatty Liver Disease among Inpatients with Schizophrenia

目的:了解住院精神分裂症患者伴发非酒精性脂肪肝情况。方法:对228例住院精神分裂症患者进行肝脏B超检查,并检测其空腹血糖、血脂、ALT、GGT、AKP等代谢指标。结果:住院精神分裂症患者伴发非酒精性脂肪肝的比例为32.5%,伴脂肪肝者体重指数、腰围、臀围明显大于不伴脂肪肝者(27.5±3.4/23.7±3.3,96.8±8.5/86.7±10.0,102.5±13.1/96.0±7.1,F=62.62～20.01,P=0.000),而除载脂蛋白A外其它血脂指标均高于不伴脂肪肝者(如:TC:4.7±1.0/4.2±1.0,TG:2.2±1.4/1.5±0.8,LDL-ch:3.3±0.9/2.8±0.8)。女性、BMI值较大、病程长、TG高、ALT较高者与患脂肪肝有关(回归系数分别为:-1.217、0.349、0.053、0.601、0.061)。结论:长期住院的慢性精神分裂症患者伴发非酒精性脂肪肝的比例高,存在一些危险因素,值得临床关注。

Objectives： To investigate the prevalence of non-alcoholic fatty liver disease among schizophrenia inpatients and to analyse its related factors. Methods： B ultrasound examinations in liver were conducted in 228 inpatients with schizophrenia, and serum chemical levels were measured, such as fasting blood glucose, total cholesterol （TC） , triglyceride （TG） , high density lipoprotein cholesterol （ HDL-C ） , low density lipoprotein cholesterol （ H）I,- C） , apolipoprotein AI （apoAI）, apolipoprotein B （apoB）, serum alanine aminotransferase （ALT）, y-glutamyltransferase （GGT） , and alkaline phosphatase （AKP） . Results： the prevalence of eomorbid non-alcoholic fatty liver disease among schizophrenia inpatients was 32. 5%, which is significantly higher than that of general population. Compared with the patients without fatty liver disease , the patients with non-alcoholic fatty liver disease had higher BMIs （ 27.5 ± 3.4/23.7 ± 3.3 ）, larger waist/hip circumference ratio （ 96. 8 ± 8.5/86. 7± 10. 0, 102. 5±13.1/96. 0 ±7.1 ） , and more serious serum lipid metabolic disturbance （ TC ： 4. 7 ± 1.0/4. 2 ± 1.0, TG ： 2.2±1.4/1.5 ± 0. 8, LDL- ch： 3.3 ±0. 9/2. 8 ± 0. 8） . Female, higher BMIs, longer disease duration, higher triglyeerides and alanine aminotransferase might be the risk factors of non-alcoholic fatty liver disease in this population （with β of- 1. 217, 0. 349j 0. 053, 0. 601 and 0. 061 respectively） . Conclusions： Schizophrenia inpatients had higher prevalence of comorbid non-alcoholic fatty liver disease.