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microRNA及其在癌症和病毒感染治疗中的应用潜力 被引量：1

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摘要 microRNA（miRNA）是内源性的通过序列特异性翻译抑制或mRNA裂解来调控基因表达的一个非蛋白质编码的大约21～25个核苷酸的小RNA家族，参与多种基本生物学过程，如细胞增殖、发育、分化、凋亡、病毒感染和癌症等。miRNA的特异性和效力显示出它们有成为癌症和病毒感染治疗剂的应用潜力。
作者 郑玉姝 赵朴 赵宏坤
机构地区 河南科技学院动物科学学院 山东农业大学动物科技学院
出处 《国外医学（药学分册）》 2006年第6期411-413,共3页 Foreign Medical Sciences(Section of Pharmarcy)
关键词 MIRNA 基因沉默 应用潜力
分类号 R346 [医药卫生—基础医学]
  • 相关文献

参考文献12

  • 1Lee RC,Feinbaum RL,Ambros V.The C.elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14[J].Cell,1993,75(5):843-854.
  • 2Lewis BP,Burge CB,Bartel DP.Conserved seed pairing,often flanked by adenosines,indicates that thousands of human genes are microRNA targets[J].Cell,2005,120(1):15-20.
  • 3Yekta S,Shih IH,Bartel DP.MicroRNA-directed cleavage of HOXB8 mRNA[J].Science,2004,304(5670):594-596.
  • 4He L,Thomson JM,Hemann MT,et al.A microRNA polycistron as a potential human oncogene[J].Nature,2005,435(7043):828-833.
  • 5Chan JA,Krichevsky AM,Kosik KS.MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells[J].Cancer Res,2005,65(14):6029-6033.
  • 6Pallante P,Visone R,Ferracin M,et al.MicroRNA deregulation in human thyroid papillary carcinomas[J].Endocr Relat Cancer,2006,13(2):497-508.
  • 7Sullivan CS,Grundhoff AT,Tevethia S,et al.SV40-encoded microRNAs regulate viral gene expression and reduce susceptibility to cytotoxic T cells[J].Nature,2005,435(7042):682-686.
  • 8Gupta A,Gartner JJ,Sethupathy P,et al.Anti-apoptotic function of a microRNA encoded by the HSV-1 latency-associated transcript[J].Nature,2006,442(7098):82-85.
  • 9Burnside J,Bernberg E,Anderson A,et al.Marek′s disease virus encodes microRNAs that map to meq and the latency-associated transcript[J].J Virol,2006,80(17):8778-8786.
  • 10孟颖,汤华,强冉,刘民,李欣.miRNA对肿瘤细胞活性影响的探讨[J].临床和实验医学杂志,2006,5(2):137-138. 被引量：6

二级参考文献7

  • 1Hutvagner G,Simard MJ,Mello CC,et al.Sequence-specific inhibi-tion of small RNA function[].Plos Biology.2004
  • 2Chan JA,Krichevsky AM,Kosik KS,et al.MicroRNA-21 Is an anti-apoptotic factor in human glioblastoma cells[].Cancer Research.2005
  • 3Boutla A,Delidakis C,Tabler M.Developmental defects by antisense-mediated inactivation of micro-RNAs2 and 13 in Drosophila and theidentification of putative target genes[].Nucleic Acids Research.2003
  • 4Meister G,Landthaler M,Dorsett Y,et al.Sequence-specific inhibi-tion of miRNA-and siRNA-inducsd RNA silencing[].Rádio Nacional de Angola.2004
  • 5Calin GA,Dumitru CD,Shimizu M,et al.Frequent deletions and down-regulation of miRNAgenes miR-15 and miR-16 at13q14 in chron-ic lymphocytic leukemia[].Proceedings of the National Academy of Sciences of the United States of America.2002
  • 6Reinhart BJ,Slack FJ,Basson M,et al.The 21-nucleotide let-7RNA regulates developmental timing in Caenorhabditis elegans[].Nature.2000
  • 7Xu P,Vernooy SY,Guo M,et al.The Drosophila microRNA Mir-14suppresses cell death and is required for normal fat metabollish[].Current Biology.2003

共引文献5

同被引文献16

  • 1康春生,浦佩玉,王广秀,李彦和,董伦,王虎.靶向表皮生长因子受体的小分子干扰RNA抑制TJ905人脑胶质瘤细胞增殖和侵袭的实验研究[J].中华医学杂志,2004,84(18):1503-1508. 被引量：12
  • 2Calin GA, Sevignani C, Dumitru CD, et al. Human mieroRNA genes are frequently located at fragile sites and genomic regions involved in cancer. Proc Natl Acad Sci USA,2004,101:2999-3004.
  • 3Li X,Zhang Y,Zhang Y,et al. Survival prediction of gastric cancer by a seven-microRNA signature. Gut ,2010,59:579-585.
  • 4Kimura S,Naganuma S,Susuki D,et al. Expression of microRNAs in squamous cell carcinoma of human head and neck and the esophagus :miR-205 and miR-21 are specific markers for HNSCC and ESCC. Oncol Rep ,2010 ,23 :1625-1633.
  • 5Agrawal R,Tran U ,Wessely O. The miR-30 miRNA family regulates Xenopus pronephros development and targets the transcription factor Xliml/Lhxl. Development ,2009,136:3927-3936.
  • 6Mellios N, Huang HS, Grigorenko A, et al. A set of differentially expressed miRNAs,including miR-30a-5p, act as post-transcriptional inhibitors of BDNF in prefrontal cortex. Hum Mol Genet, 2008, 17: 3030-3042.
  • 7Patnaik SK, Kannisto E, Yendamuri S. Overexpression of microRNA miR-30a or miR-191 in A549 lung cancer or BEAS-2B normal lung cell lines does not alter phenotype. PLoS One ,2010,5 :e9219.
  • 8Li J, Donath S, Li Y, et al. miR-30 regulates mitochondrial fission through targeting p53 and the dynamin-related protein-1 pathway. PLoS Genet ,2010,6: e1000795.
  • 9Quick QA, Gewirtz DA. An accelerated senescence response to rad- iation in wild-type p53 glioblastoma multiforme cells. J Neurosurg, 2006,105:111-118.
  • 10贾志凡,浦佩玉,康春生,王广秀,张志勇,裘明哲,黄强.隔蛋白7逆转裸鼠移植胶质瘤的恶性表型[J].中华肿瘤杂志,2008,30(1):3-7. 被引量：3

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国外医学（药学分册）
2006年 第6期

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