microRNA及其在癌症和病毒感染治疗中的应用潜力
被引量:1
摘要
microRNA(miRNA)是内源性的通过序列特异性翻译抑制或mRNA裂解来调控基因表达的一个非蛋白质编码的大约21~25个核苷酸的小RNA家族,参与多种基本生物学过程,如细胞增殖、发育、分化、凋亡、病毒感染和癌症等。miRNA的特异性和效力显示出它们有成为癌症和病毒感染治疗剂的应用潜力。
出处
《国外医学(药学分册)》
2006年第6期411-413,共3页
Foreign Medical Sciences(Section of Pharmarcy)
参考文献12
-
1Lee RC,Feinbaum RL,Ambros V.The C.elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14[J].Cell,1993,75(5):843-854.
-
2Lewis BP,Burge CB,Bartel DP.Conserved seed pairing,often flanked by adenosines,indicates that thousands of human genes are microRNA targets[J].Cell,2005,120(1):15-20.
-
3Yekta S,Shih IH,Bartel DP.MicroRNA-directed cleavage of HOXB8 mRNA[J].Science,2004,304(5670):594-596.
-
4He L,Thomson JM,Hemann MT,et al.A microRNA polycistron as a potential human oncogene[J].Nature,2005,435(7043):828-833.
-
5Chan JA,Krichevsky AM,Kosik KS.MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells[J].Cancer Res,2005,65(14):6029-6033.
-
6Pallante P,Visone R,Ferracin M,et al.MicroRNA deregulation in human thyroid papillary carcinomas[J].Endocr Relat Cancer,2006,13(2):497-508.
-
7Sullivan CS,Grundhoff AT,Tevethia S,et al.SV40-encoded microRNAs regulate viral gene expression and reduce susceptibility to cytotoxic T cells[J].Nature,2005,435(7042):682-686.
-
8Gupta A,Gartner JJ,Sethupathy P,et al.Anti-apoptotic function of a microRNA encoded by the HSV-1 latency-associated transcript[J].Nature,2006,442(7098):82-85.
-
9Burnside J,Bernberg E,Anderson A,et al.Marek′s disease virus encodes microRNAs that map to meq and the latency-associated transcript[J].J Virol,2006,80(17):8778-8786.
-
10孟颖,汤华,强冉,刘民,李欣.miRNA对肿瘤细胞活性影响的探讨[J].临床和实验医学杂志,2006,5(2):137-138. 被引量:6
二级参考文献7
-
1Hutvagner G,Simard MJ,Mello CC,et al.Sequence-specific inhibi-tion of small RNA function[].Plos Biology.2004
-
2Chan JA,Krichevsky AM,Kosik KS,et al.MicroRNA-21 Is an anti-apoptotic factor in human glioblastoma cells[].Cancer Research.2005
-
3Boutla A,Delidakis C,Tabler M.Developmental defects by antisense-mediated inactivation of micro-RNAs2 and 13 in Drosophila and theidentification of putative target genes[].Nucleic Acids Research.2003
-
4Meister G,Landthaler M,Dorsett Y,et al.Sequence-specific inhibi-tion of miRNA-and siRNA-inducsd RNA silencing[].Rádio Nacional de Angola.2004
-
5Calin GA,Dumitru CD,Shimizu M,et al.Frequent deletions and down-regulation of miRNAgenes miR-15 and miR-16 at13q14 in chron-ic lymphocytic leukemia[].Proceedings of the National Academy of Sciences of the United States of America.2002
-
6Reinhart BJ,Slack FJ,Basson M,et al.The 21-nucleotide let-7RNA regulates developmental timing in Caenorhabditis elegans[].Nature.2000
-
7Xu P,Vernooy SY,Guo M,et al.The Drosophila microRNA Mir-14suppresses cell death and is required for normal fat metabollish[].Current Biology.2003
共引文献5
-
1吴建桥.miRNA的基因调控原理与临床研究进展[J].湖北职业技术学院学报,2007,10(3):105-109. 被引量:2
-
2徐锡涛,童锦禄,冉志华.microRNA与消化道肿瘤的研究进展[J].胃肠病学,2008,13(10):626-628.
-
3赵广义,赵健,李伟,高杰,杨彤涛,裘秀春,范清宇,马保安.microRNA-192抑制物对骨肉瘤细胞系SOSP_9607增殖和凋亡的影响[J].中国肿瘤临床,2010,37(7):365-368. 被引量:5
-
4黎伯胜,肖斌,刘真(综述),邹全明(审校).microRNA在胃肠道肿瘤中的研究进展[J].中国肿瘤临床,2010,37(11):656-659. 被引量:1
-
5冯建超,周进学,靳根峰,刘勇.miR-542-3P对肝细胞癌诊断和预后判断的临床价值研究[J].实验与检验医学,2020,38(6):1060-1063. 被引量:3
同被引文献16
-
1康春生,浦佩玉,王广秀,李彦和,董伦,王虎.靶向表皮生长因子受体的小分子干扰RNA抑制TJ905人脑胶质瘤细胞增殖和侵袭的实验研究[J].中华医学杂志,2004,84(18):1503-1508. 被引量:12
-
2Calin GA, Sevignani C, Dumitru CD, et al. Human mieroRNA genes are frequently located at fragile sites and genomic regions involved in cancer. Proc Natl Acad Sci USA,2004,101:2999-3004.
-
3Li X,Zhang Y,Zhang Y,et al. Survival prediction of gastric cancer by a seven-microRNA signature. Gut ,2010,59:579-585.
-
4Kimura S,Naganuma S,Susuki D,et al. Expression of microRNAs in squamous cell carcinoma of human head and neck and the esophagus :miR-205 and miR-21 are specific markers for HNSCC and ESCC. Oncol Rep ,2010 ,23 :1625-1633.
-
5Agrawal R,Tran U ,Wessely O. The miR-30 miRNA family regulates Xenopus pronephros development and targets the transcription factor Xliml/Lhxl. Development ,2009,136:3927-3936.
-
6Mellios N, Huang HS, Grigorenko A, et al. A set of differentially expressed miRNAs,including miR-30a-5p, act as post-transcriptional inhibitors of BDNF in prefrontal cortex. Hum Mol Genet, 2008, 17: 3030-3042.
-
7Patnaik SK, Kannisto E, Yendamuri S. Overexpression of microRNA miR-30a or miR-191 in A549 lung cancer or BEAS-2B normal lung cell lines does not alter phenotype. PLoS One ,2010,5 :e9219.
-
8Li J, Donath S, Li Y, et al. miR-30 regulates mitochondrial fission through targeting p53 and the dynamin-related protein-1 pathway. PLoS Genet ,2010,6: e1000795.
-
9Quick QA, Gewirtz DA. An accelerated senescence response to rad- iation in wild-type p53 glioblastoma multiforme cells. J Neurosurg, 2006,105:111-118.
-
10贾志凡,浦佩玉,康春生,王广秀,张志勇,裘明哲,黄强.隔蛋白7逆转裸鼠移植胶质瘤的恶性表型[J].中华肿瘤杂志,2008,30(1):3-7. 被引量:3
二级引证文献2
-
1孙即奎,贾志凡,浦佩玉,王广秀,张安玲,杨卫东.反义miR-30a-5p抑制脑胶质瘤生长的体内实验研究[J].国际肿瘤学杂志,2013,40(2):149-152.
-
2孙即奎,浦佩玉,张安玲,王广秀,杨卫东,贾志凡.反义miR-19a/b抑制LN229人脑胶质瘤生长的体内实验研究[J].中华神经外科杂志,2013,29(11):1110-1113. 被引量:2
-
1何倩婷,王安训.微小RNA-181a及其在恶性肿瘤中的作用[J].国际口腔医学杂志,2013,40(1):51-54. 被引量:1
-
2隗思媛,周雪宏,李淑艳.线粒体LncRNA[J].中国生物化学与分子生物学报,2016,32(12):1303-1307. 被引量:3
-
3沈亚欧,林海建,张志明,高世斌,潘光堂.植物逆境miRNA研究进展[J].遗传,2009,31(3):227-235. 被引量:11
-
4祁磊,苗俊英.长非编码RNA[J].生命的化学,2011,31(3):378-384. 被引量:3
-
5李粉,陈华群.microRNAs在肌肉中的作用研究进展[J].生物技术通报,2010,26(11):62-67.
-
6姜宁,陈启军.生物基因组非蛋白质编码转录组学及研究进展[J].中国基础科学,2009,11(6):15-19. 被引量:2
-
7韩国培育出可生产抗癌辅助成分的克隆猪[J].吉林农业农村经济信息,2005(9):17-17.
-
8安凤霞,卢宝伟,梁鸣,唐焕伟,李富恒.萱草microRNAs生物信息学及与冷冻相关microRNAs的分析[J].植物生理学报,2014,50(4):483-487. 被引量:4
-
9陈洁,林海建,潘光堂,张志明,张彪,沈亚欧,覃成,张谦,赵茂俊.利用深度测序技术检测玉米根系和叶片中已知的microRNAs[J].遗传,2010,32(11):1175-1186. 被引量:10
-
10Zizhen Yang,Lei Zhu,Fangqin Li,Jing Wang,Huan Wan,Yujun Pan.Bone marrow stromal cells as a therapeutic treatment for ischemic stroke[J].Neuroscience Bulletin,2014,30(3):524-534. 被引量:16