小蓟饮子及其配伍对关木通减毒作用的实验研究

Experimental Study of Xiaojiyinzi and Its Compatibility of Herbal Ingredients in Reducing the Nephrotoxicity of Caulis Aristolochiae Manshuriensis

目的了解小蓟饮子通过哪种配伍途径能够减轻关木通的肾毒性。方法将大鼠随机分为7个组,分别给予生理盐水(A组)、关木通水煎液(B组)、小蓟饮子水煎液(C组)及关木通分别与小蓟饮子中君臣佐使不同配伍的水煎液灌胃(D、E、F、G组),3周后测定相关肾功能指标并对肾组织形态学进行检查。结果小蓟饮子,关木通与小蓟饮子中君药、臣药配伍组肾功能与正常组相比差异无显著性意义(P>0.05),肾脏组织形态学改变也轻微。结论小蓟饮子全方及其君药、臣药能够减轻关木通肾毒性。

Objective To find out by which method of compatibility of herbal ingredients Xiaojiyinzi can reduce the nephrotoxicity of caulis aristolochiae manshuriensis. Methods Rats were divided into seven groups randomly. Groups A, B, C, D, E, F, G were fed with physiological saline, caulis aristolochiae manshuriensis decoction, Xiaojiyinzi decoction or caulis aristolochiae manshuriensis mixed into chief, adjuvant, assistant and courier herbs of Xiaojiyinzi respectively decoction. After three weeks, kidney function and kidney tissue morphology were detected. Results There was no obvious difference of kidney function between groups C, D, E and group A （P〉0,05）, and the change of kidney tissue morphology of groups C, D, E was little. Conclusion Xiaojiyinzi, chief or adjuvant herbs in Xiaojiyinzi can reduce the nephrotoxicity of caulis aristolochiae manshuriensis.