针药预防胆固醇性胆囊结石的实验研究

Experimental Research on Prevention of Cholesterol Gallstone with Fangshi Capsule Combining with Auricular-plaster Therapy

目的观察耳压及防石胶囊预防胆固醇性胆囊结石的作用。方法将75只豚鼠随机分成5组。空白组喂普通饲料,模型组喂胆固醇结石诱石饲料,熊去氧胆酸(UDCA)组喂胆固醇结石诱石饲料加UDCA,防石组喂胆固醇结石诱石饲料加防石胶囊,耳压组喂胆固醇结石诱石饲料并每天耳穴按压。结果实验2个月后发现:胆囊结石发生率及胆汁中钙离子浓度依次为:模型组>3个治疗组(耳压组、UDCA组、防石组)>空白组,统计学上差异有显著性意义。结论耳压及防石胶囊能预防胆囊胆固醇性结石的形成,其机制可能和它们能分别降低胆汁中钙离子浓度有关。

Objective To observe the effect of Fangshi capsule with Auricular-plaster therapy on experimental gallstone guinea pigs. Method Seventy five female guinea pigs were randomly divided into five groups blank group, model group, UDCA group, Fangshi group and Auricular piaster group. All animals were fed with corresponding feeds for two months. Results There were significant difference of gallstone rate and Ca^2＋ of bile of five groups, model group〉therapy group （Auricular-plaster group, UDCA group, Fangshi group） 〉blank group. Conclusion Fangshi capsule combining with Auricular-plaster therapy could prevent the formation of cholesterol gallstone possibly by reducing the calciurn ion concentration in the bile.