益肾蠲痛汤并PVP治疗骨质疏松脊椎压缩骨折腰背疼痛的临床研究

The Clinical Study on Yi Shen Juan Tong Decoction Combined With Percutaneous Vertebroplasty in Treatment of Osteoporotic Vertebral Compression Fractures

目的探讨益肾蠲痛汤并PVP治疗骨质疏松脊椎骨折腰背疼痛的疗效及机理。方法总结96例确诊为骨质疏松症的患者,进行回顾性研究,分别采用中药结合PVP治疗(A组)、单纯PVP治疗(B组)和单纯中药治疗(C组),通过对其临床症候记分、骨密度值及激素水平的改变情况进行统计学分析以评价三种治疗方案的疗效差异。结果三组总有效率分别为A组96.97%;B组87.33%;C组73.78%。三组总体疗效经Ridit分析,A组高于B组和C组,有非常显著性差异(P<0.01);B组与C组相比较,两组有显著性差异(P<0.05)。结论益肾蠲痛汤并PVP治疗骨质疏松脊椎骨折腰背疼痛能显著改善临床症状,提高骨密度及性激素水平,近、远期疗效肯定。

Objective：To explore the clinical effect and mechanism of Yi Shen Juan Tong Decoction combined with percutaneous vertebroplasty in treatment of osteoporotic vertebral compression fractures. Methods： To retrospectively study all 96 patients with osteoporotic vertebral compression fractures, who were treated respectively with Chinese medicine＆PVP（A group） ,PVP（B group） and Chinese medicine（C group）. To analyse statistically the score of symptoms and physical signs, BMD level and sex hormone level ,so as to evaluate the clinical effect of all three therapies. Result：The total effective rate of all three groups were：96.97% in A group,87.33% in B group and 7.3. 78% in C group. Through Ridit analysis,the general effect of A group was better than B group and C group with very significant difference（P〈0.01） ;The difference between B group and C group was significant（P〈 0.05 ）. Conclusion： The therapy of Yi Shen Juan Tong Decoction combined with percutaneous vertebroplasty can significantly improve symptoms and physical signs in treating osteoporotic vertebral compression fractures and can increase bone density and sex hormone.