血尿酸和血脂代谢紊乱对冠状动脉病变的影响

Relationship between level of plasma lipids,uric acid and coronary artery affection

目的研究高尿酸血症及血脂代谢紊乱对冠状动脉粥样硬化病变的影响。方法收集所有行冠状动脉造影检查的患者327例,按检查结果分为正常对照组113例,单支病变组70例,双支病变组72例、多支病变组72例。检测所有患者血清中的血尿酸,脂蛋白(α)[Lp(α)],总胆固醇(TG),甘油三酯(TC),低密度脂蛋白(LDL),高密度脂蛋白(HDL),载脂蛋白(B)(apoB)的水平,进行统计学分析。结果血尿酸水平在以上各组间无统计学意义上差异,而Lp(α),TG,TC,LDL高于正常对照组,多元相关回归分析显示:冠脉病变计分和血尿酸及TC无相关关系,LDL,HDL,apoB,TG,Lp(α)与冠心病显著相关,而TC与冠心病无独立相关。结论尿酸与冠状动脉病变无明显相关,而血脂及糖代谢紊乱与冠状动脉粥样病变显著相关。

AIM To study the effect of uric acid and plasma lipids on coronary artery affection. METHODS Three hundred and twenty-seven cases of patients were examined by coronary angiography and by the results of which they were divided into four groups by degree of coronary artery affection ： normal control group （ n = 113 ）, single vessel lesion group （ n = 70 ）, double vessel lesion group （ n = 72 ） and multivessel lesion group（n =72）. Lp（α） , uric acid and plasma lipids were measured by usual procedures and the results were statistically analyzed. RESULTS There was no association between the uric acid level and the extent and the severity of coronary artery. The levels of UA, TG, TC, Lp （α） , LDL-C and apoB were different among the groups, especially between normal control group and multivessel lesion group. CONCLUSION Uric acid level may have no effect on the coronary artery affection. The extent of coronary artery lesion is mainly related to plasma lipids metabolic disorder.