曲美他嗪治疗不稳定型心绞痛的疗效观察

Curative effect of trimetazidine on patients with unstable angina pectoris

目的观察曲美他嗪治疗不稳定型心绞痛(UAP)的临床疗效和安全性。方法74例UAP患者分为常规对照组和曲美他嗪治疗组,各37例。后者服用曲美他嗪20 mg,3次/d,余用药同对照组。观察两组治疗前后临床疗效,心电图及动态心电图变化,患者的药物耐受性,不良反应。结果治疗后曲美他嗪组总疗效率86.5%,对照组总有效率62.2%,心电图改善率分别为72.9%和48.6%,动态心电图缺血发作次数、总缺血时间均有显著减少(P<0.05),且患者耐受性良好,无不良反应。结论在常规治疗的基础上加用曲美他嗪能安全、更有效地控制UAP。

AIM To evaluate the effect and safety of trimetazidine in patients with unstable angina pectoris （UAP）. METHODS Seventy-four patients with UAP were randomly divided into two groups： routine treatment group and routine plus trimetazidine group with 20 mg three times a day. and the results were compared. The curative effect and the changes of ECG, Hoher, the tolerence and side effect to trimetazidine were compared before and after the treatment. RESULTS After the treatment, the rate of curative effect of trimetazidine treatment group was 86.5% while that of routine group was 62.2%. The improvement rate of ECG of two groups was 72.9% and 48.6% , respectively. Hoher showed that the times of ischemia and the total time of ischemia of the trimetazidine group decreased significantly （ P 〈 0.05）. The patients had good tolerance to trimetazidine and no obvious side effects were found. CONCLUSION On the basis of regular treatment, combined treatment of trimetazidine can more effectively control UAP.