^(13)C-美沙西定呼气试验评估肝硬化患者肝储备功能的研究

Measurement of Liver Compensatory Function for Patients with Cirrhosis by Means of ^(13)C-Methacetin Breath Test

目的探讨13C-美沙西定呼气试验评估肝硬化患者肝储备功能的临床价值。方法随机选取健康志愿者30例为对照组,肝硬化患者82例为试验组,服用13C-美沙西定75mg后,通过呼气质谱仪检测10个时间段呼出的13CO2含量,得出DOB曲线、MV曲线及CUM曲线,MVmax30、CUM30及CUM120值,并与常规肝功能生化指标及Child-Pugh分级行相关性分析。结果MVmax30、CUM30及CUM120值在对照组及肝硬化ChildA、B、C各组间,除ChildA、B组的CUM120值外,均有显著性差异(P<0·05),MVmax30、CUM30及CUM120值与部分肝功能生化指标及Child-Pugh分级计分有相关性。结论13C-美沙西定呼气试验是1种定量评估肝硬化患者肝储备功能的有效方法。

Objective To explore the clinical value of ^13C-Methacetin breath test （^13C-MBT） for the evaluation of liver compensatory function for patients with cirrhosis. Methods 82 cases of cirrhosis patients and 30 matched healthy controls were studied. ^13C-MBT was performed after oral administration of 75 mg of ^13C-MBT. Abundance of ^13CO2 expired at 10 time-points were tested using isotope mass spectrometer. DOB, MV and CUM curves and MVmax 30,CUM 30 and CUM 120 were achieved. These results were compared with conventional liver function tests and Child- Pugh score. Results MVm~, 30, CUM 30 and CUM 120 were significantly different among controls and cirrhosis Child A, B and C （ P 〈 0. 05 ）, except CUM 120 between groups of Child A and B. MVmax 30,CUM 30 and CUM 120 were significantly correlated with liver function test and Child-Pugh score. Conclusion ^13C-MBT could be an accurate method for evaluation of liver compensatory function for patients with cirrhosis.