VEGF-C在人乳腺癌中的表达及意义

Expression of VEGF-C in human breast cancer and its implication

目的:探讨血管内皮生长因子-C(VEGF-C)在人乳腺癌组织中的表达及其临床意义。方法:采用免疫组化方法(SP法)检测乳腺纤维腺瘤12例;乳腺囊性增生35例(其中I级增生7例,Ⅱ级增生16例,Ⅲ级增生12例);乳腺癌45例中VEGF-C的表达情况。结果:VEGF-C在乳腺纤维腺瘤中无表达,在乳腺囊性增生中的表达率为20.0%(7/35),其中I级为0,Ⅱ级12.5%(2/16),Ⅲ级41.7%(5/12)。在乳腺癌中的表达率为71.1%(32/45),与乳腺增生比较差异显著(P<0.05)。VEGF-C在Ⅲ+Ⅳ期乳腺癌中的表达率明显高于I+Ⅱ期乳腺癌,其相应淋巴结的转移率也愈高(P<0.05),但与患者年龄、肿瘤大小、雌激素、孕激素受体状况等无明显相关性。结论:VEGF-C在乳腺癌发生恶变的过程中起着重要作用,其高表达预示患者易于发生淋巴结转移。

Objective：To investigate the relationship between the expression of vascular endothelial growth factor-C （VEGF-C） proteins and biological behavior of breast cancer. Methods： Immunohistochemical staining was used to detect the expression of VEGF-C proteins in 12 cases of mammary fibroma, 35 cases of mammary cystic hyperplasia, 45 cases of breast cancer. Results ： VEGF-C protein was absent in mammary fibroma, the expression rate of VEGF-C protein in mammary cystic hyperplasia was 20.0% （7/35）,The expression rate of VEGF-C in breast cancer was 71. 1% （ 32/45 ）, and it was significantly different compared with mammary cystic hyperplasia（ P 〈 0.05）. The expression of VEGF-C in Ⅲ and Ⅳ phase of breast cancer were significantly higher than that in Ⅰ and Ⅱ phase, so was the axillary lymph node metastasis rate （P 〈 0.05）.However,it was not correlated with the age of patient,tumor size,the expression of ER and PR. Conclusions ：VEGF-C may take part in occurrence and progression of breast cancer.Over-expression of VEGF-C is related to high possibility of lymphatic metastasis.