TGF-β1、Endoglin在口腔鳞癌中的表达及意义

Expression of TGFβ1、Endoglin in human oral squamous cell carcinoma and their significances

目的:探讨口腔鳞状细胞癌组织中TGF-β1、Endogl(inCD105)的表达和临床意义。方法:采用免疫组化法检测TGF-β1、Endoglin在42例口腔鳞癌和14例正常口腔黏膜中的蛋白表达,分析与组织病理学分级以及TGF-β1和Endoglin的表达之间的关系。结果:TGF-β1在正常口腔黏膜和口腔鳞癌中均有表达,在口腔鳞癌中随癌的分化程度降低而表达增强。在低分化鳞癌中表达最高(48.94±11.01)。Endoglin在正常口腔黏膜中不表达,在口腔鳞癌组织中均可见表达,主要见于癌巢及其周围,其MVD值在低度分化鳞癌标本染色明显升高(16.73±3.63)。两者的表达在口腔鳞癌中呈显著正相关(r=0.648,p<0.01)。结论:TGF-β1、Endoglin在口腔鳞癌组织中呈过表达,可能在口腔鳞癌的发生发展过程中发挥一定作用,是反映预后的重要参考指标。

Objective：To study the expression of transforming growth factorβ1 （TGF-β1） ,Endoglin （CD105）in oral squamous cell carcinoma （OSCC） .Method： 42 cases of OSCC and 14 cases of normal oral mucosa were examined with immunohistochemical staining for the expression of TGF-β1, Endoglin and the relationship of expression of TGF-β1 and Endoglin was evaluated.Result： Immunoreaction to TGF-β1 were expressed in OSCC and normal oral mucosa. TGF-β1 were overexpressed in OSCC compared with those in normal oral mucosa, the expression of TGF-β1 reached peak in poor differentiated OSCC （48.94±11.01）.Expression of CD105 was negative in all normal oral mucosa tissues and positive in all OSCC tissues.In OSCC,immunostaiming to CD105 was found both in the nest and those adjacent to the nest,and CD105-MVD increased sharply as differentiation became poor （16.73±3.63）.The expression of TGF-β1 sigificantly correlated with the MVD of CD105（r=0.648, p 〈0.01 ） Conclusion： TGF-β1, Endoglin may play an important role in OSCC occurrence and development. TGF-β1 and Endoglin could evaluate the prognosis of patient.