缺氧缺血性脑病新生儿血浆生长激素和催乳素水平变化及其临床意义

Serum growth hormone and prolactin levels in neonates with hypoxic-ischemic encephalopathy

目的探讨血浆生长激素(GH)和催乳素(PRL)在新生儿缺氧缺血性脑病(HIE)发病过程中的水平变化以及二者之间作用的相互关系。方法采用放射免疫分析法测定54例HIE急性期、恢复期和20例对照组患儿血浆GH,PRL水平。结果急性期中、重度HIE患儿与轻度和对照组比较,血浆GH水平明显降低,而PRL水平明显增高(P<0.01);恢复期HIE各组与对照组血浆GH,PRL水平比较差异无显著性(P>0.05);中、重度HIE患儿急性期与恢复期比较,血浆GH水平明显降低,而PRL水平明显升高(P<0.01);急性期血浆GH与PRL水平呈高度负相关(r=-0.8759,P<0.01)。结论GH,PRL参与了新生儿HIE的发生和发展过程,急性期血浆GH,PRL水平与HIE病情程度密切相关。

Objective To investigate the levels and roles of serum growth hormone （GH） and prolactin （PRL） in neonatal hypoxic-ischemic encephalopathy （HIE）. Methods Serum GH and PRI, levels were measured by radioimmunoassay in 54 neonates with HIE （20 mild, 19 moderate and 15 severe HIE） at the acute and convalescence stages. Twenty normal neonates were used as controls. Results Serum GH levels were significantly lower, but PRI, levels were significantly higher in moderate and severe HIE neonates at the acute stage compared with those of controls and mihl HIE neonates （P 〈0.01 ）. There were noticeable differences in serum levels of GH and PRL between the moderate and severe HIE cases （P 〈0.01 ）. During the convalescence stage, serum GH levels increased and PRL levels decreased in moderate and severe HIE neonates compared with those at the acute stage （P 〈 0.01 ） ; serum GH and PRL levels in each sub-group of HIE restored to the levels of controls. There was a closely negative correlation between GH and PRL levels at the acute stage of HIE （ r = - 0. 8759, P 〈 0.01 ）. Conclusions GH and PRL might be involved in the pathopbysiological process of HIE, The levels of GH and PRL closely relate to the severity of HIE at the acute stage.