垂体瘤转化基因在多发性骨髓瘤患者中表达的研究

Expression of Pituitary Tumor-Transforming Gene in Patients with Multiple Myeloma

为了研究垂体瘤转化基因(pituitarytumor-transforminggene,PTTG)在老年多发性骨髓瘤(multiplemyelo-ma,MM)患者中的表达并分析它与MM发生的关系,采用RT-PCR方法检测33例MM患者及10例正常对照者骨髓单个核细胞中PTTG的表达。结果表明MM患者PTTG在MM中的表达水平(0.3415±0.2172)明显高于正常对照组(0.0590±0.0233)(P<0.05)。结论PTTG的过度表达可能与MM的发生发展有关,这为MM的发病机制及其基因靶向治疗的研究提供了新的思路。

To explore the expression of pituitary tumor-transforming gene （PTFG） in elderly patients with multiple myeloma （MM）and its relationship with MM, the expressions of PTTG mRNA were detected in bone marrow mononuclear cells （BMMNC） from 33 patients with MM and 10 normal controls by using reverse transcriptase-polymerase chain reaction （RT-PCR） . The results showed that the expression of PTTG mRNA in MM patients （0.3415 ±0. 2172） was significantly higher than that in normal controls （0.0590 ± 0.0233 ） （P 〈 0.05 ）. It is concluded that the overexpression of oncogene PTTG may be related to genesis and progression of MM. It provided a new ideas to study the pathogenesis and gene therapy for MM patients.