福善美防治老年男性骨质丢失的临床研究

Clinical Study on Efficacy of Fosamax in Preventing Bone Loss in Aged Males

目的：研究阿伦膦酸钠制剂福善美防治老年男性骨质丢失的作用。方法：将48例老年男性受试者随机分为福善美组和对照组。福善美组服用福善美和钙剂，对照组只服用钙剂，均用药1年。研究开始和结束时检测受试者腰椎和股骨上端骨密度，以及血清骨钙素（s—BGP）和尿羟脯氨酸与肌酐比值（Hyp／Cr）。结果：均用药1年后，福善美组腰椎骨密度略有上升（P〉0．05），而股骨颈、Ward龟三角区和股骨粗隆骨密度则显著上升（P〈0.05）；对照组各处骨密度均明显下降（P〈0.05）。对照组s—BGP和Hyp／Cr比值均上升（P〈0.05），而福善美组则无显著变化。结论：福善美可通过抑制骨转换而防止老年男性骨质丢失。

Objective：To study the effect of preventing bone loss of Fosamax in aged males. Methods： Forty - eight aged males were randomly divided in into Fosamax group treated with Fosamax and calcium preparation and the control group with calcium preparation alone. The therapeutic course for both groups was 1 year. Bone mineral density （BMD） of lumbar vertebra and hip, serum osteocalcin （ s - BGP） and urinary hydroxyproline / ereatinine ratio （Hyp/Cr） were determined at the beginning and ending of the study. Results： After 12 moths＇ treatment, the BMD of lumbar vertebra increased slightly （ P 〉 0.05 ） , while BMD of femoral neck, Ward＇s triangular space and femoral trochanter increased significantly （ P 〈 0.05 ）. But the BMD in different parts in the control group was all decreased significantly. Moreover, s - BGP and Hyp/Cr ratio were all raised in the control group but unchanged in the Fosamax group. Conclusion： Fosamax could prevent bone loss in aged males through inhibiting bone turnover.