1,6—二磷酸果糖治疗新生儿窒息致心肌损伤35例临床分析

Study on fructose-1,6-diphosphate(FDP)treatment for neonate's cardiac injury caused by suffocation in 35 cases

目的 探讨1，6——二磷酸果糖（1，6-diphosphate，FDP）治疗新生儿窒息致心肌损伤的疗效和预后。方法 将35例患儿随机分为治疗组和对照组，常规治疗为对照组，在常规治疗基础上加用FDP250～300mg·kg．^-1·d^-1，做心肌酶谱测定。结果 治疗组总有效率32／35（91．43％），对照组总有效率25／33（75．84％）。两组比较，差异有统计学意义（P〈0．01）。结论 外源性FDP有显著改善新生儿缺氧性心肌损伤患儿，并可改善预后，减少后遗症的发生。

Objective To investigate the FDP＇s curative effect in treating neonate＇ s cardiac injury caused by suffocation and its prognosis, Methods 35 cases were divided into two groups. The therapy group had regular treatment plus FDP 250- 300 mg· kg.^-1 · d^-1 and the control group had regular treatment. Enzyme of cardiac muscle was determined. Results The effective rate of therapy group was 32/35 （91,43%）, and the control group was 25/33 （75,84%）. The difference of two groups was significant（ P 〈 0.01） .Conclusion The extrinsic FDP was effective in the treatment for neonate＇s cardiac injury caused by suffocation, can improve the prognosis and reduce the sequela.