纳洛酮治疗急性脑梗死量效关系的临床研究

Relationship between the dosage and efficiency of naloxone in the treatment of acute cerebral infarction

目的 观察纳洛酮治疗急性脑梗死（ACI）的量效关系，探讨纳洛酮治疗ACI的最佳剂量。方法 筛选60例ACI患者随机分为4组，每组15例，分别用1．6mg／d、2．8mg／d、3．6mg／d、5．2mg／d剂量的纳洛酮静脉滴注，每日1次连续15d，观察临床疗效，并且绘出量效关系曲线。结果 1．6mg／d纳洛酮治疗基本无效；2．8mg／d纳洛酮治疗略有好转。量效关系曲线处于上升阶段；3．6mg／d纳洛酮治疗有效，量效关系曲线处于快速上升阶段；3．6—5．2mg／d纳洛酮治疗显著好转，但从量效关系曲线来看上升趋势不再明显。结论 根据量效关系曲线分析，纳洛酮治疗急性脑梗死的最佳剂量在3．6—5．2mg／d之间。

Objective To observe the relationship between the dosage and efficiency of naloxone in the treatment of acute cerebral infarction（ACI） and explore its best dosage for the treatment of ACI. Methods 60 patients with ACI were randomly divided into 4 groups.They were treated with different dosage of naloxone （1.6 mg,2,8 nag, 3.6 mg,5.2 mg） by intravenous drip for 14 days, respectively. The clinical therapeutic effect in each group was observed and the curve of relationship between the dosage and efficiency was drawn. Results No effect was found with the dosage of 1.6 mg naloxone; the symptoms got better slightly with the dosage of 2.8 mg naloxone, its curve was at the ascending stage; obvious effect was exhibited with 3.6 mg naloxone, its curve was at rapidly ascending stage;the effect was the best with the dosage of 3.6 mg to 5.2 mg naloxone, but the ascending tendency of the curve became less. Conclusion The best dosage of naloxone to treat acute cerebral infarction may be at the range of 3.6 - 5.2 mg.