肾移植术后巨细胞病毒和结核杆菌感染情况分析

Infection of cytomegalovirus and tubercle bacillus in renal allograft recipients

目的分析肾移植术后巨细胞病毒和结核杆菌感染情况。方法165例肾移植受者术后应用免疫抑制剂后,采用免疫细胞化学法测定外周血白细胞巨细胞病毒pp65抗原,用荧光定量PCR检测患者结核杆菌DNA。结果165例肾移植受者中,102例(61.7%)术后发生巨细胞病毒感染,白细胞中巨细胞病毒阳性细胞数明显高于术前。3例(1.7%)术后受者检测出结核杆菌DNA。结论肾移植术后由于免疫抑制剂的应用,易发生感染并发症,因此在治疗过程中应注重病原学监测,以降低移植受者感染率。

Objective To analyse the infection of cytomegalovirus and tubercle bacillus in the renal allograh recipients. Methods One hundred and sixty-five recipients were treated with immunosupprecssant after transplantation. CMV-pp65 antigen was determined by immunocytochemical method, TB DNA was detected by fluorescent quantitation PCR. Results One hundred and two of 165 recipients（61.7 % ） infected CMV after transplantation, the CMV positive cell numbers in WBC of recipients was significantly increased after transplantation,and 3 of 165 （1.7%） recipients infected TB after operatation. Conclusion The incidence of CMV and TB infection in renal allograft recipients is high because of immunosupprecssant application. The pathogen detection should be monitored.