新桥医院1230例肺癌患者多因素预后分析

Prognostic factors of patients with lung cancer:retrospective analysis of 1 230 cases in Xinqiao Hospital

目的通过对大样本肺癌资料的多因素预后分析，建立具有临床实用价值的预后模型，为肺癌防治提供科学依据。方法对新桥医院1999年1月1日～2004年1月1日期间具有明确组织学类型和病理分期的1230例肺癌患者，经壹阅病历并随访，回顾性分析、比较影响肺癌患者生存的预后因素。结果共随访1230例患者，失访99人，失访率8％；有效病例1131例。Cox单因素及多因素分析表明：家破史、病理分期、手术类型、化疗方案是否含铀剂及其周期是独立的影响肺癌患者预后的因素。结论家族史、病理分期、手术类型，是否合铂剂方案化疗及其周期是独立影响肺癌患者预后的因素。

Objective To analyze the prognostic factors of lung cancer,and to find some clues for prevention and a clinic treatment of lung cancer in future. Methods The data of 1 230 hospitalized patients with lung cancer in Xinqiao Hospital from January 1, 1999 to January 1,2004 were reviewed and followed up. The factors which might impact on the patients＇ prognosis were analyzed including general information of the patients themselves, the tumor data,and different treatment manners. Results A total of 1 230 cases were enrolled in this ,study and 1131 of them were followed up to the end-point of the study with 8%（99 cases） of loss to follow-up. Cox regression indicated that family history, tumor stage, operation manner, application of platinum-based chemotherapy and its cycles were independent prognostic factors of patients with lung cancer. Conclusion Tumor family history, tumor stage, operation manner, application of platinum-based chemotherapy and its cycles are independent prognostic factors of lung cancer patients,