59例乳腺癌的临床与病理分析

Clinical and pathological analysis in 59 cases of breast cancer

目的研究59例乳腺癌的临床特征、病理与乳腺癌中ER、PR、p53、CerbB-2等的表达情况。方法对59例患者的临床资料、病理类型及免疫组化结果进行回顾性分析。结果乳腺癌中ER、PR、p53、CerbB-2表达阳性率为27.1%、54.2%、47.5%、55.9%。p53表达阳性与乳腺癌组织学分级差异有统计学意义(P<0.05),与淋巴结转移差异有统计学意义(P<0.01)。结论乳腺癌中,p53表达与CerbB-2表达相关,p53表达阳性不仅与细胞癌变有关,而且与癌细胞的浸润和转移有关。

Objective To research the clinical and pathological results in 59 eases of breast cancer, especially the expression of ER,PR,p53,CerbB-2. Methods A retrospective analysis was made on 59 eases of breast cancer from Jan. 2004 to Oct. 2005. All of them were treated in our hospital. Results The positive rates of ER, PR, p53, CerbB-2 in breast cancer were 27. 1%, 54. 2 %, 47. 5 %, 55.9 % respectively. A statistically significant relation was found between the presence of p53 and lymph node metastasis（P 〈0.01）,the presence of p53 was also associated with the histological typing in breast cancer. （P〈0. 05）. Conclusion There is a correlation between the expression of p53 and CerbB-2. p53 is assoicated with carcinogenesis development and local invasion in breast cancer.