胎儿羊水、血清β_2—微球蛋白水平分析

Detection of β_2-microglobulin reference ranges in fetal blood and amniotic fluid

目的检测15-38w胎儿羊水、血液β2-微球蛋白（β2-MG）水平，为胎儿泌尿系统疾病等胎儿发育异常的诊断和预后评估提供理论依据。方法应用B超引导下经母腹羊膜腔、脐静脉穿刺术获取121例孕15—38w胎儿羊水和81例19—38w胎儿脐血（经胎血鉴定），应用Bayer1650全自动生化分析仪β2-微球蛋白水平，并进行分组统计。结果胎儿血β2-微球蛋白水平，随孕周增加而下降，但15-34w间无显著差异，而均与35w后组有显著差异；羊水β2-微球蛋白水平。也随孕周增加而下降。但15—30w间无显著差异，31—38w间无显著差异，而两者间组有显著差异，有统计学意义。结论胎儿血、羊水β2-微球蛋白水平随孕周增加而下降，有统计学意义。

Objective： To investigate the reference ranges of β2-microglobulin in the fetal blood and amniotic fluid. Methods： β2-microglobulin were determined from 81 fetal blood samples of 19 -38 weeks gestation. And 121 fetal amniotic fluid samples of 15 -38 weeks gestation. ; Pure fetal blood was obtained by cordocentesis under coentinuous ultrasound guidance, Results： During 15 - 18 weeks＇ gestation , fetal β2- MG are 10. 5 ± 3.6 in the amniotic fliud, 19 -22 weeks＇ gestation , fetal β2- MG are 12. 2 ± 4. 2 in the amniotic fluid and 4. 85 ±0. 58in the serum, 23 -26 weeks＇ gestation , fetal β2- MG are 12.1 ± 4. 1 in the amniotic fluid and 4. 76 ±0. 55 in the serum, 27 -30 weeks＇ gestation , fetal β2- MG are 10. 5 ± 2.7 in the amniotie fluid and 4.8 ±0. 59 in the serum, 31 -34 weeks＇ gestation , fetal β2- MG are 5.1 ± 1.9 in the amniotic fluid and 4. 1 ±0. 62 in the serum, 35 - 38 weeks＇ gestation , fetal β2- MG are 12. 2 ± 4. 2 in the amniotic fluid and 4. 85 ±0. 62 in the serum. Conclusion： β2- microglobulin are decrease with gestation age. （ P 〈 0. 05）, All information will improve our knowledge of fetal medicine and be useful in evaluation of fetal kidney＇s funtion.