妊娠期糖代谢异常性巨大儿与成纤维细胞生长因子的关系

Study on the relationship between fetal macrosomia of gestational diabetes mllitus,gestational impared glucose tolerance and fibroblast growth factor-2

目的探讨孕妇血清成纤维细胞生长因子2（FGF-2）水平测定对糖代谢异常性巨大儿有无预测价值。方法采用酶联免疫方法检测孕34-37w母血清中FGF-2水平。结果（1）糖代谢正常组孕妇血清FGF-2（3．35±2．2ng／ml），而异常组≥18．9±2．8ng／ml，两者差异显著。（2）糖代谢异常组巨大儿母血清FGF-2水平为（34．6±4．3ng／ml）。正常组为（23．34±3．7ng/ml），两组比较差异性有显著性（P〈0．05）。结论糖代谢异常组孕妇血清FGF-2水平明显高于正常组，其水平与新生儿体重呈正相关，说明孕妇血清FGF-2水平与糖代谢异常性巨大儿（GDM—MS）有相关性。

Objective： To investigate whether maternity serum fibrnblast growth factor - 2 （ FGF - 2） can be as a predictor of gestational diabetes mellitus （GDM） and gestational impared glucose tolerance （GIGT）. Methods： The serum fibroblast growth factor - 2 （ FGF - 2） levelof pregnant women during 34 - 37 gestational week was analized by revers enzyme linked immunosorbernt assay （E LISA）. Results： （1） The maternity serum FGF- 2 concentration of normal pregnant women group was （3.35 ± 2. 2） ng/ml： The maternity serum FGF- 2 concentration of the glucose intolerant pregnant women group was （18. 9 ±2. 8） ng/ml, Whereas there was significant difference in normal pregnant women and glucose intolerant pregnant women. （2） The maternity serum FGF-2 bevel of glucose intolerant pregnant women and fetal macrosomia was （34. 6 ±4. 3 ） ng/ml; The maternity serum FGF - 2 concentration of normal pregnant women and fetal macrosomia was （23.3 ±3. 7） ng/ml. The difference between the glucose intolerant pregnant women and fetal macrosomia group and normal pregnant women and fetal macrosomia group WaS statistically significace （ P 〈 0.05 ）. Conclusion： The maternity serum FGF -2 level of glucose intolerant pregnant women group is much higher than that of normal glucose group. The maternity serum FGF -2 level of glucose intolerant pregnant women group positively correlated with the weight of neonate newborn. It proveds maternity serun FGF- 2 level is correlated with gestational diabetes mellitus fetal maernsomia （GDM- MS）.