肝病患者凝血及纤溶指标检测的意义

Significance of coagulation and fibrinolysis detection in hepatic diseases

目的探讨肝病与凝血及纤溶指标的关系。方法使用Sysmex CA-1500全自动血凝仪对30例正常对照组,111例肝病组的凝血醇原时间(PT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(Fbg)、D-二聚体(D-D)进行检测分并组比较。结果PT、APTT、Fbg、D-D在急性肝炎组与正常组差异无显著意义(P>0.05),而在漫性肝炎、肝硬化及重症肝病患者与正常组差异有显著意义(P<0.01)。结论说明PT、APTT、Fbg、D-D检测对轻度肝病的意义不大,但可预计重症肝病患者是否有出血倾向及可能伴有隐匿型DIC,以上凝血及纤溶指标,有助于预防DIC的发生、判断病情的预后和指导临床治疗。

Objective To explore the significance of coagulation and fibrinolysis detection in hepatic diseases. Methods Serum PT, APTT, Fbg and D-D levds were detected with Sysmex CA-1500 auto-coagulation detector in 30 cases of normal persons and 111 eases of hepatic diseases, and the results of the different groupa were compared. Results The levels of PT, APTT, Fbg and D-D had no significant difference between the acute hepatitis group and the normal group, P 〉0.05. The levels of PT, APTT and D-D in the chronic hepatitis, hepatocirrhosis and heavy hepatic disease groups were much higher and Fbg was much lower than those in the normal group, P 〈 0.01. Conclusions The detection of PT, APTT, Fb g and D-D can prognosticate the bleeding possibility, and these indices are beneficial to DIC prevention and dinical treatment.