血管紧张素Ⅱ对动脉粥样硬化斑块发生和发展过程中炎性因子的影响作用

The Effects of AngiotensinⅡ on the Inflammatory Factors during the Atherosclerotic Plaques Forming and Developing

动脉粥样硬化(AS)是一种炎症性疾病。血管紧张素Ⅱ(AngⅡ)是肾素-血管紧张素系统(RAS)中最重要的炎性介质,AngⅡ可以诱导动脉粥样硬化斑块中多种细胞表达多种炎性因子,同时多种炎性因子也可反作用于AngⅡ,形成复杂的反馈关系。通过抑制AngⅡ,可以减轻AS斑块局部的炎性反应,从而达到抑制AS的作用。

Atheroscleresis is an inflammation disease. Angiotensin Ⅱ is the most important inflammatory mediator in RenalnAngiotensin System（ RAS）. Angiotensin can induce some inflammatory cells to express inflammatory factors ; and at the same time, inflammatory factors also have effects on Ang Ⅱ, so they form complex feedback relations. By inhibiting Ang Ⅱ , inflammatory reactions can be relieved in AS plaques;thus AS can be impressed.