人工晶体表面纤维蛋白膜形成的实验研究

An experimental study of fibrinous mem-bane formation on posterior chamber intraocular lens

在光镜和电镜下动态观察兔眼后房型人工晶体囊袋内植入术后的人工晶体表面,发现明显的纤维蛋白膜、炎性细胞和色素沉着。纤维蛋白膜在术后第1天即已形成,第7天最明显,术后14天有所减少。并发现,前房内纤维蛋白渗出是纤维蛋白膜形成的基础,与人工晶体表面的巨噬细胞、纤维母细胞样细胞、巨细胞一起共同参与此膜的形成,并使之机化。纤维蛋白膜和炎性细胞以人工晶体边缘、光学部分与袢连接处和定位孔处为多。分析纤维蛋白膜形成的原因可能是人工晶体刺激、血-房水屏障破坏和免疫反应所致。

The pathological changes and morphological features of fibrinous membrane formation on the posterior chamber lens were studied in rabbits with Irj ght microscopy and scanning electron microscopy. It was found that there were fibrinous membrane, inflammatory cells and pigment deposits on the intraocular lens (IOL) surface. On the 1st postoperative day fi rinous membrane on IOL was formed, on the 7th postoperative day enlarged markedly, on the 14th postoperative day reduced in size. It is und fothat the fibrinous exudate is the basic constituent of the membrane. The membrane on the surface of IOL is composed of fibrin along with macrophages, fibroblastlike cells and giant cells,and eventually fibrosis occurs. The fibrinous membrane and inflmmatory cells on IOL accumulate primarily on the lens edge, optical portion, positioning hole of IOL, and haptic-optic junction. It is suggestedthat fibrinous membrane formation on IOL is closely related to the irritation of PMMA IOL, the breakdown of blood-aqueous barrier and the immune response.