三种非甾体消炎药滴眼剂的抗炎研究

A study on the anti-inflammatory effects of nonsteroidal antiinflammatory ophthalmic solutions

非甾体消炎药双氯灭痛,酮基布洛芬和萘普生对兔眼前房穿刺引起的房水蛋白升高的抑制率分别为76.98%;61.71%和20.83%。对穿刺引起的缩瞳抑制作用以酮基布洛芬作用最强,在各检查时间点,其瞳孔横经与对照组比较均有显著差异性(P<0.05)。双氯灭痛仅在15和30分钟时有显著差异(P<0.05)。萘普生无明显作用。实验为双氯灭痛和酮基布洛芬作为消炎滴眼剂提供了实验依据。

The topical effects of nonsteroidal anti-inflammatory agents, diclofenac, ketoprofen and naproxen, on reducing ocular inflammation were studied by aqueous paracentesis in rabbit eyes. In the aqueous humor, the inhibition rate of protein,the centration was 76.98% by diclofenac, 61.71% by ketoprofen and 20.83% by naproxen. The inhibition effect of ketoprofen on miosis is strongeer than that of placebo solution (vehicle) ; ketoprofen has significant difference at any examination time statistically (p<0.05) , and diclofenac has significant differences only at 15 and 30 minutes (p<0.05) . Naproxen did not show any distinct difference in the pupillary size from the control group at any examination time during the experiment.Theese results indicate that diclofenac and ketoprofen may be used as topical anti-inflammatory agents in ophthalmology