气相色谱法测定吲哚美辛三七冰片栓中冰片的含量

GC-FID quantitative determination of borneol in compound indomethacin suppositories

目的:建立气相色谱内标法直接测定吲哚美辛三七冰片栓中冰片的含量。方法:色谱柱为聚乙二醇(PEG)-20M 毛细管柱(0.32 mm×30 m,0.25 μm);柱温140℃;进样口温度220℃;检测器温度220℃;载气为氮气。结果:龙脑浓度在0.52～0.93 mg·mL^(-1)范围内呈良好的线性关系(r=0.9999),冰片平均回收率为99.91%,RSD 为0.25%。结论:本方法操作简便、快速、准确,可作为冰片的定量分析方法。

Objective ： A method was established for the quality analysis of borneol in compound indomethacin suppositories, methods：Using the capillary column gas chromatography with PEG -20M column （0.32 mm × 30 m, 0.25 μm ） The column temperature was 140 ℃, the injector temperature was 220 ℃ , the detector temperature was 220 ℃, supporting gas ： N2. Results： A linearity and correlation coefficient was yielded from 0.52 to 0. 93 mg · mL^-1 （ r = 0. 9999）. The mean recovery of the borneol was 99. 91% （ RSD = 0. 25 % ）. Conclusion： The method appeares to be accurate, rapid and simple. It can be applied to the quality control of borneol.