头孢硫脒治疗急、慢性肾盂肾炎的疗效分析

Efficacy analysis of cefathiamidin on acute and chronic pyelonephritis

目的评价头孢硫脒治疗急、慢性肾盂肾炎的临床疗效和安全性。方法急、慢性肾盂肾炎131例，每日给予头孢硫脒3．0～6．0g,分2次静脉滴注，疗程10～14d，观察临床症状和细菌学变化及不良反应。结果临床总有效率87.0％，细菌转阴率84．0％，其中革兰阳性球菌转阴率92．7％。结论头孢硫脒用于治疗急、慢性肾盂肾炎效果好,不良反应轻微，对革兰阳性球菌引起的感染可作为首选药物。

Objective To review clinical efficacy and safety profile of cefathiamidin treatment on acute and chronic pyelonephritis. Method One hundred and thirty-one patients with acute and chronic pyelonephritis were intravenously administered cefathiamidin 3.0～6. 0g/d, bid, for 10～14 days and clinical symptoms and bacteriological findings as well as side-effects were obsered. Result Overall clinical effective rate is 87.0% and bacterium negative rate is 84.0% in which the negative rate of Gram-positive cocci was 92. 7%. Conclusion Cefathiamidin is effective with fewer side-effects in the treatment on acute and chronic pyelonephritis and can be used for the first choice of drugs for the treatment of the infection caused by Grampositive cocci.