血友病合并HIV/HCV感染者肝功能异常的相关因素分析

Correlation factor analysis of abnormal liver functions among hemophiliacs co-infected with HIV/HCV

目的探讨血友病合并艾滋病病毒/丙型肝炎病毒(HIV/HCV)感染者CD4计数和HIV病毒载量,与HIV/HCV重叠感染者肝功能异常的相关性。方法观察了63例血友病合并HIV/HCV感染者,据CD4计数和HIVRNA阳性情况,比较肝功能异常的发生率与细胞免疫、HIVRNA阳性的相关性。结果CD4≤200细胞/mm3者20例中,有肝功能异常者14例,与CD4计数>200细胞/mm3组肝功能异常发生率有统计学差异(P<0.05)。HIVRNA阳性的38例中,有肝功能异常者22例,与HIVRNA阴性组肝功能异常发生率有统计学差异(P<0.05)。肝功能异常组的CD4计数较肝功能正常组为低,HIVRNA定量较正常组为高,其差异有统计学意义(P<0.05)。结论CD4计数和HIVRNA阳性情况,可作为血友病合并HIV/HCV感染者肝功能异常的预测因素。

Objective To investigate the relation between CD4 counts, viral loads and abnormal liver function among hemophiliacs co-infected with HIV/HCV. Method Retrospective study was designed to analysis the immunological function,HIVRNA viral loads,prevalence of abnormal liver functions among 63 cases of hemophiliaes co-infected with HIV/ HCV. Results In 20 cases of hemophiliacs with CD4 count below 200,14 had abnormal liver functions. Compared to those with CD4 count above 200, the prevalence of abnormal liver function in cases with CD4 count below 200 had significant statistical difference（ P 〈 0.05）. In 38 HIV positive cases 22 had abnormal liver functions. Compared to HIV negative cases, the prevalence of abnormal liver function in HIV positive cases had significant statistical difference（ P 〈0.05）. Compared to the cases with normal liver functions, the CD4 count was lower than in cases with abnormal liver functions, but HIVRNA was higher, and there was significant statistical difference（P〈 0.05）. Conclusion CD4 count and positive HIVRNA may be used as predictors of abnormal liver functions in hemophiliacs co-infected with HIV/HCV.