心肌尔康冲剂对阿霉素致小鼠中毒性心炎的防治作用

Protective and Therapeutic Effect of Xinjierkang Granule on Adriamycin - induced Toxi Myocarditis in Mice

阿霉素１５ｍｇ／ｋｇｉｐ，隔日１次，连续５次，可引起小鼠中毒性心肌炎。心肌尔康冲剂２０，１０，５ｇ／ｋｇｉｇ给药，能改善中毒性心肌炎小鼠的异常心电图，对抗心肌酶（ＬＤＨ、ＣＫ）的升高；病理学及超微结构观察显示心肌损害减轻。当阿霉素剂量增至３０ｍｇ／ｋｇ·次时，小鼠出现死亡，心肌尔康冲剂能降低小鼠的死亡率。表明该药对阿霉素所致的小鼠中毒性心肌炎有一定的防治作用。

Thxic myocarditis in mice was induced by adriamycin 1.5mg/kgip once every other day for 5times.Hinjierliang(XJEK)granule was given ig to the mice in dosages of 20,10,5g/kg daily for 10 and 20 days to observeits protective and therapeutic effect.The results showed that XJEK granule can improve the abnornial ECG,lower the serum levelof lactate dehydrtigenase(LDH)and creatine kinase(CK).and decrease the pathological and ultrasstructural damage of my-ocardium.Death occurred when the dosage of adriamyein was increased to 3.0mg/kg and XJEK granule can reduce the deathrate.It is suggested that XJEK granule exeris protective and therapeutic effect on adriamycin-induced toxic myocarditis in