游泳加中药淫羊藿综合疗法对去势大鼠骨代谢生化指标的作用

Therapeutic effects of combining swimming exercise and Chinese medicine(Yin Yang Huo)biochemical indicators of bone metabolism of on postmenopausal(ovariectomized)rats

目的:探讨运动与中药淫羊藿综合疗法治疗绝经后骨质疏松症的疗效及机理,为防治绝经后骨质疏松找到更适宜的方法提供理论依据。方法:采用去势大鼠模型,分为去卵巢后服药组(M),去卵巢后运动并服药组(SM),去卵巢后运动组(S),去卵巢组(OVX),空白对照组(C)。去势后7天运用运动、中药淫羊藿以及运动加中药联合等几种干预方法防治去卵巢大鼠发生的骨质疏松。去势第70天取血清测试各组钙(Ca)、磷(P)、碱性磷酸酶(ALP)及抗酒石酸酸性磷酸酶(StrACP)。结果:各组血清钙、磷的含量没有显著性差异(P>0.05)。SM组、M组、S组及C组血清ALP活性均高于OVX组并有显著性差异(P<0.05)。S组、M组、SM组StrACP活性较OVX组低并有显著性差异(P<0.05)。结论:运动和中药淫羊霍综合疗法能通过促骨形成、抑制骨吸收防治去卵巢大鼠发生绝经后骨质疏松,其疗效要优于单纯运动及中药组。

Purpose： To determine the efficacy of and the mechanism for treating postmenopausal osteoporosis with a combination of physical exercise and traditional Chinese medicine（TCM）, in order to provide a theoretical basis for improving the prevention and treatment of postmenopausal osteoporosis through this method. Method： A total of 30, seven - month - old, female rats were randomly divided into five groups. These were： Ovariectomized Group（S）, Ovarieetomized and Combination of Swirmming Exercise and TCM Group（SM） and the Control Group（C）. On the seventh day following ovariectomy（ for all groups save Group C）, treatment began for the M, S and SM Groups. On the seventieth day, blood serum was taken from all of the rats and examined for Ca, P, ALP, and StrACP levels. Results： No significant differences were found in serum levels of Ca and P for all groups（ P 〉 0.05）. ALP levels in the SM, M, S and C Groups were all higher than in the OVX Group, with significant diference（ P 〈 0. 05 ）. StrACP in the S, M and SM Groups were all lower than in the OVX Group, with significant difference（ P 〈 0.05）. Conclusion：The combination of physical exercise and TCM（ Ying Yang Huo）is a more eftective method of treatment for postmenopansal osteoporosis than exercise - only or TCM - only methods of treatment. The mechanism for its efficacy is that this form of therapy helps to improve bone formation, while halting bone reabsorption.